Beta-band functional connectivity is reorganized in Mild Cognitive Impairment after combined computerized physical and cognitive training

Manousos A. Klados, Charis Styliadis, Christos A. Frantzidis, Evangelos Paraskevopoulos, Panagiotis D. Bamidis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Physical and cognitive idleness constitute significant risk factors for the clinical manifestation of age-related neurodegenerative diseases. In contrast, a physically and cognitively active lifestyle may restructure age-declined neuronal networks enhancing neuroplasticity. The present study, investigated the changes of brain's functional network in a group of elderly individuals at risk for dementia that were induced by a combined cognitive and physical intervention scheme. Fifty seniors meeting Petersen's criteria of Mild Cognitive Impairment were equally divided into an experimental (LLM), and an active control (AC) group. Resting state electroencephalogram (EEG) was measured before and after the intervention. Functional networks were estimated by computing the magnitude square coherence between the time series of all available cortical sources as computed by standardized low resolution brain electromagnetic tomography (sLORETA). A statistical model was used to form groups' characteristic weighted graphs. The introduced modulation was assessed by networks' density and nodes' strength. Results focused on the beta band (12–30 Hz) in which the difference of the two networks' density is maximum, indicating that the structure of the LLM cortical network changes significantly due to the intervention, in contrast to the network of AC. The node strength of LLM participants in the beta band presents a higher number of bilateral connections in the occipital, parietal, temporal and prefrontal regions after the intervention. Our results show that the combined training scheme reorganizes the beta-band functional connectivity of MCI patients. Identifier: NCT02313935
Original languageEnglish
Article number55
JournalFrontiers in Human Neuroscience
Issue numberFEB
Publication statusPublished - 29 Feb 2016

Bibliographical note

Copyright © 2016 Klados, Styliadis, Frantzidis, Paraskevopoulos and Bamidis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Funding: European CIP-ICTPSP. 2008.1.4 Long Lasting memories (LLM) project (Project No. 238904) ( LLM run from June 2009 to March 2012 under the co-ordination of the author PB and it was a partnership of 5 EU Member countries (Austria, France, Greece, Spain, and the Cyprus).


  • Aging
  • Brain plasticity
  • Cognitive training
  • Electroencephalography
  • Graph theory
  • Mild cognitive impairment
  • Physical exercise
  • Resting states


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