Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease

Richard A. Armstrong, D. Myers

Research output: Contribution to journalArticle

Abstract

The density and spatial pattern of immunostained beta/A4 deposits and mature senile plaques (SP) stained by the Glees method were compared in Alzheimer's diseased brain. Thirty-seven percent of the variance in Glees SP density in a tissue could be explained by beta/A4. Both lesions were clustered with the beta/A4 clusters often larger than the Glees SP clusters. Beta/A4 and Glees SP cluster size were not correlated in a tissue. The size of Glees SP clusters was positively correlated with SP density but no correlation could be detected for beta/A4. Hence, the density and spatial pattern of beta/A4 deposits in most tissues did not predict the development of Glees SP.
Original languageEnglish
Pages (from-to)262-264
Number of pages3
JournalNeuroReport
Volume3
Issue number3
Publication statusPublished - Mar 1992

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Amyloid Plaques
Alzheimer Disease
Brain

Keywords

  • density pattern
  • spatial pattern
  • immunostained beta/A4 deposits
  • mature senile plaques
  • Alzheimer's disease
  • brain

Cite this

Armstrong, Richard A. ; Myers, D. / Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease. In: NeuroReport. 1992 ; Vol. 3, No. 3. pp. 262-264.
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Armstrong, RA & Myers, D 1992, 'Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease', NeuroReport, vol. 3, no. 3, pp. 262-264.

Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease. / Armstrong, Richard A.; Myers, D.

In: NeuroReport, Vol. 3, No. 3, 03.1992, p. 262-264.

Research output: Contribution to journalArticle

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