Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease

Richard A. Armstrong, D. Myers

Research output: Contribution to journalArticle

Abstract

The density and spatial pattern of immunostained beta/A4 deposits and mature senile plaques (SP) stained by the Glees method were compared in Alzheimer's diseased brain. Thirty-seven percent of the variance in Glees SP density in a tissue could be explained by beta/A4. Both lesions were clustered with the beta/A4 clusters often larger than the Glees SP clusters. Beta/A4 and Glees SP cluster size were not correlated in a tissue. The size of Glees SP clusters was positively correlated with SP density but no correlation could be detected for beta/A4. Hence, the density and spatial pattern of beta/A4 deposits in most tissues did not predict the development of Glees SP.
Original languageEnglish
Pages (from-to)262-264
Number of pages3
JournalNeuroReport
Volume3
Issue number3
Publication statusPublished - Mar 1992

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Keywords

  • density pattern
  • spatial pattern
  • immunostained beta/A4 deposits
  • mature senile plaques
  • Alzheimer's disease
  • brain

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