Bifurcation in blood oscillatory rhythms for patients with ischemic stroke: A small scale clinical trial using laser Doppler flowmetry and computational modeling of vasomotion

Alexey Goltsov*, Anastasia V. Anisimova, Maria Zakharkina, Alexander I. Krupatkin, Viktor V. Sidorov, Sergei G. Sokolovski, Edik Rafailov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We describe application of spectral analysis of laser Doppler flowmetry (LDF) signals to investigation of cerebrovascular haemodynamics in patients with post-acute ischemic stroke (AIS) and cerebrovascular insufficiency. LDF was performed from 3 to 7 days after the onset of AIS on forehead in the right and left supraorbital regions in patients. Analysis of LDF signals showed that perfusion in the microvasculature in AIS patients was lower than that in patients with cerebrovascular insufficiency. As a result of wavelet analysis of the LDF signals we obtained activation of the vasomotion in the frequency range of myogenic oscillation of 0.1 Hz and predominantly nutritive regime microcirculation after systemic thrombolytic therapy of the AIS patients. In case of significant stroke size, myogenic activity, and nutritive pattern microhaemodynamics were reduced, in some cases non-nutritive pattern and/or venular stasis was revealed. Wavelet analysis of the LDF signals also showed asymmetry in wavelet spectra of the LDF signals obtained in stroke-affected and unaffected hemispheres in the AIS patients. A mechanism underlying the observed asymmetry was analyzed by computational modeling of vasomotion developed in Arciero and Secomb (2012). We applied this model to describe relaxation oscillation of arteriole diameter which is forced by myogenic oscillation induced by synchronous calcium oscillation in vascular smooth muscle cells. Calculation showed that vasomotion frequency spectrum at the low-frequency range (0.01 Hz) is reciprocally modulated by myogenic oscillation (0.1 Hz) that correlates with experimental observation of inter-hemispheric variation in the LDF spectrum.

Original languageEnglish
Article number160
Number of pages11
JournalFrontiers in Physiology
Volume8
DOIs
Publication statusPublished - 23 Mar 2017

Bibliographical note

Copyright © 2017 Goltsov, Anisimova, Zakharkina, Krupatkin, Sidorov, Sokolovski and Rafailov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Keywords

  • acute ischemic stroke
  • blood flow oscillation
  • cerebrovascular haemodynamics
  • laser Doppler flowmetry
  • vasomotion modeling

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