Biocompatible choline based ionic salts: Solubility in short-chain alcohols

J.M. Lopes, A.B. Paninho, M.F. Môlho, A.V.M. Nunes, A. Rocha, N.M.T. Lourenço, V. Najdanovic-Visak

Research output: Contribution to journalArticlepeer-review


In this work, we report data on solubility of choline chloride and choline acetate in short-chain linear alcohols (ethanol, 1-propanol and 1-butanol) at various temperatures. Furthermore, we synthesize two choline derivatives: hydrogen choline chloride glutarate ([CholGlut][Cl]) and hydrogen choline chloride succinate ([CholSucc][Cl]). Their characterization and solubility in short-chain alcohols as a function of temperature are also included. Activity coefficients were calculated and their comparisons with ideal solutions were discussed. The experimental data were correlated successfully by means of the semi-empirical Grant equation.
Original languageEnglish
Pages (from-to)99-105
JournalJournal of Chemical Thermodynamics
Publication statusPublished - 1 Dec 2013


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