TY - JOUR
T1 - Biological and clinical insights from genetics of insomnia symptoms
AU - Lane, Jacqueline M.
AU - Jones, Samuel E.
AU - Dashti, Hassan S.
AU - Wood, Andrew R.
AU - Aragam, Krishna G.
AU - van Hees, Vincent T.
AU - Strand, Linn B.
AU - Winsvold, Bendik S.
AU - Wang, Heming
AU - Bowden, Jack
AU - Song, Yanwei
AU - Patel, Krunal
AU - Anderson, Simon G.
AU - Beaumont, Robin N.
AU - Bechtold, David A.
AU - Cade, Brian E.
AU - Haas, Mary
AU - Kathiresan, Sekar
AU - Little, Max A.
AU - Luik, Annemarie I.
AU - Loudon, Andrew S.
AU - Purcell, Shaun
AU - Richmond, Rebecca C.
AU - Scheer, Frank A.J.L.
AU - Schormair, Barbara
AU - Tyrrell, Jessica
AU - Winkelman, John W.
AU - Winkelmann, Juliane
AU - Martinsen, Amy E.
AU - Skogholt, Anne H.
AU - Brumpton, Ben
AU - Winsvold, Bendik S.
AU - Sivertsen, Børge
AU - Willer, Cristen J.
AU - Bragantini, Daniela
AU - Kallestad, Håvard
AU - Janszky, Imre
AU - Guzey, Ismail C.
AU - Zwart, John Anker
AU - Nielsen, Jonas B.
AU - Nilsen, Kristian B.
AU - Hveem, Kristian
AU - Fritsche, Lars
AU - Pedersen, Linda M.
AU - Strand, Linn B.
AU - Gabrielsen, Maiken E.
AU - Johnsen, Marianne B.
AU - Lie, Marie U.
AU - Engstrøm, Morten
AU - Sand, Trond
AU - HUNT All In Sleep
PY - 2019/2/25
Y1 - 2019/2/25
N2 - Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.
AB - Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.
UR - https://www.scopus.com/pages/publications/85062283398
UR - https://www.nature.com/articles/s41588-019-0361-7
UR - http://sleepdisordergenetics.org/informational/data/
U2 - 10.1038/s41588-019-0361-7
DO - 10.1038/s41588-019-0361-7
M3 - Letter, comment/opinion or interview
C2 - 30804566
AN - SCOPUS:85062283398
SN - 1061-4036
VL - 51
SP - 387
EP - 393
JO - Nature Genetics
JF - Nature Genetics
IS - 3
ER -