Biophotonics approach for the study of leukocyte activation

Daria N. Chernova, Sergei G. Sokolovski, Alexey Yu Vorobev, Alexander E. Moskalensky

Research output: Chapter in Book/Report/Conference proceedingConference publication

Abstract

Leukocytes are the main cells of immune system, but also contribute to other systems and participate in pathogenesis of different diseases. In particular, leukocytes are involved in the progression of diabetic retinopathy due to their hyperactivation in diabetes. However, a connection between diabetes and the dysfunction of leukocytes is poorly understood. For a more complete picture, studies of the leukocytes activation under the influence of various substances are necessary. Arachidonic acid (AA) and its metabolites are the strongest activating factors of leukocytes. However, the studies involving AA are complicated because it is water-insoluble. Here we describe the method to study activation using photolabile analogs of AA.

Original languageEnglish
Title of host publicationSaratov Fall Meeting 2019
Subtitle of host publicationOptical and Nano-Technologies for Biology and Medicine
EditorsValery V. Tuchin, Valery V. Tuchin, Elina A. Genina
PublisherSPIE
ISBN (Electronic)9781510637184
DOIs
Publication statusPublished - 9 Apr 2020
Event7th International Symposium on Optics and Biophotonics: Optical and Nano-Technologies for Biology and Medicine, SFM 2019 - Saratov, Russian Federation
Duration: 23 Sep 201927 Sep 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11457
ISSN (Print)1605-7422

Conference

Conference7th International Symposium on Optics and Biophotonics: Optical and Nano-Technologies for Biology and Medicine, SFM 2019
CountryRussian Federation
CitySaratov
Period23/09/1927/09/19

Bibliographical note

Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Keywords

  • Arachidonic acid
  • Biophotonics
  • Caged arachidonic acid
  • Dysfunction of leukocytes
  • Intracellular calcium
  • Jurkat cell
  • Photolabile analogs
  • Single cell optical control

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