BPROMPT: a consensus server for membrane protein prediction

Paul D. Taylor, Teresa K. Attwood, Darren R. Flower

Research output: Contribution to journalArticlepeer-review

Abstract

Protein structure prediction is a cornerstone of bioinformatics research. Membrane proteins require their own prediction methods due to their intrinsically different composition. A variety of tools exist for topology prediction of membrane proteins, many of them available on the Internet. The server described in this paper, BPROMPT (Bayesian PRediction Of Membrane Protein Topology), uses a Bayesian Belief Network to combine the results of other prediction methods, providing a more accurate consensus prediction. Topology predictions with accuracies of 70% for prokaryotes and 53% for eukaryotes were achieved. BPROMPT can be accessed at http://www.jenner.ac.uk/BPROMPT.
Original languageEnglish
Pages (from-to)3698-3700
Number of pages3
JournalNucleic Acids Research
Volume31
Issue number13
DOIs
Publication statusPublished - Jul 2003

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