Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

Stephen B. Simons, Douglas A. Caruana, Meilan Zhao, Serena M. Dudek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A 1 adenosine receptors (A 1 Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A 1 R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.

Original languageEnglish
Pages (from-to)23-25
Number of pages3
JournalNature Neuroscience
Issue number1
Publication statusPublished - 1 Jan 2012

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Copyright © 2011, Springer Nature


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