Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

Stephen B. Simons; Douglas A. Caruana; Meilan Zhao; Serena M. Dudek

doi:10.1038/nn.2962

Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

Stephen B. Simons, Douglas A. Caruana, Meilan Zhao, Serena M. Dudek^*

^*Corresponding author for this work

National Institute of Environmental Health Sciences

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

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Abstract

Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A 1 adenosine receptors (A 1 Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A 1 R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.

Original language	English
Pages (from-to)	23-25
Number of pages	3
Journal	Nature Neuroscience
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/nn.2962
Publication status	Published - 1 Jan 2012

Bibliographical note

Funding

We thank D. Armstrong and members of the Dudek laboratory for their input on the manuscript. This research was supported by the Intramural Research Program of the US National Institutes of Health, National Institute of Environmental Health Sciences (Z01 ES 100221).

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10.1038/nn.2962

Caffeine-induced synaptic potentiation in hippocampal CA2 neurons
Copyright © 2011, Springer Nature
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Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

Abstract

Bibliographical note

Funding

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