Calcitonin gene-related peptide: multiple actions, multiple receptors

Research output: Contribution to journalArticlepeer-review


Calcitonin gene-related peptide (CGRP) shows diversity both in its effects and its receptors. It is likely to have roles as a neurotransmitter, neuromodulator, local hormone and trophic factor. Its effects include rapid changes in neuronal activity, relaxation of many type of smooth muscle, actions on metabolism and changes in gene expression. Receptor heterogenecity has been revealed from experiments comparing agonist potency ratios and antagonists affinities. the evidence from these approaches is reviewed in this article and a speculative receptor classification scheme is proposed. Some of the likely future directions for CGRP research are discussed. © 1993.

Original languageEnglish
Pages (from-to)23-51
Number of pages29
JournalPharmacology and Therapeutics
Issue number1
Publication statusPublished - 1992


  • amino acid sequence
  • animals
  • calcitonin
  • gene-related peptide
  • humans
  • molecular sequence data receptors
  • calcitonin receptors
  • cell surface


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