Cancer Inhibition and In Vivo Osteointegration and Compatibility of Gallium-Doped Bioactive Glasses for Osteosarcoma Applications

Lucas Souza, Filipe V. Ferreira, Joao H. Lopes, Jose Angelo Camilli, Richard A. Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Traditional osteosarcoma therapies tend to focus solely on eradicating residual cancer cells and often fail to promote local bone regeneration and even inhibit it due to lack of precise control over target cells, i.e., the treatment affects both normal and cancer cells. Typically, multistep procedures are required for optimal efficacy. Here, we found that a silica-based bioactive material containing 3 mol % gallium oxide selectively kills human osteosarcoma cells and presents excellent in vivo osteointegration, while showing no local or systemic toxicity. Cell culture media conditioned with the proposed material was able to kill 41% of osteosarcoma cells, and no significant deleterious effect on normal human osteoblasts was observed. In addition, rats treated with the gallium-doped material showed excellent material–bone integration with no sign of local toxicity or implant rejection. Systemic biocompatibility investigation did not indicate any sign of toxicity, with no presence of fibrosis or cellular infiltrate in the histological microstructure of the liver and kidneys after 56 days of observation. Taken together, these results show that synergistic bone regeneration and targeted cancer therapy can be combined, paving the way toward new bone cancer treatment approaches.
Original languageEnglish
Pages (from-to)45156-45166
Number of pages11
JournalACS Applied Materials and Interfaces
Volume14
Issue number40
Early online date28 Sep 2022
DOIs
Publication statusPublished - 12 Oct 2022

Bibliographical note

© 2022 The Authors. Published by American Chemical Society. This article is published under a Creative Commons Attribution License 4.0 (CC-BY)

Keywords

  • Animals
  • Bone Neoplasms/drug therapy
  • Gallium/chemistry
  • Glass/chemistry
  • Humans
  • Osteosarcoma/drug therapy
  • Rats
  • Silicon Dioxide

Fingerprint

Dive into the research topics of 'Cancer Inhibition and In Vivo Osteointegration and Compatibility of Gallium-Doped Bioactive Glasses for Osteosarcoma Applications'. Together they form a unique fingerprint.

Cite this