Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses

Fàtima Crispi; Edgar Hernandez-Andrade; Maurice M.A.L. Pelsers; Walter Plasencia; Jesus Andres Benavides-Serralde; Elisenda Eixarch; Ferdinand le Noble; Asif Ahmed; Jan F.C. Glatz; Kypros H. Nicolaides; Eduard Gratacos

doi:10.1016/j.ajog.2008.06.056

Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses

Fàtima Crispi, Edgar Hernandez-Andrade, Maurice M.A.L. Pelsers, Walter Plasencia, Jesus Andres Benavides-Serralde, Elisenda Eixarch, Ferdinand le Noble, Asif Ahmed, Jan F.C. Glatz, Kypros H. Nicolaides, Eduard Gratacos

Research output: Contribution to journal › Article › peer-review

Abstract

Objective - The purpose of this study was to assess cardiac function and cell damage in intrauterine growth-restricted (IUGR) fetuses across clinical Doppler stages of deterioration.

Study Design - One hundred twenty appropriate-for-gestational-age and 81 IUGR fetuses were classified in stages 1/2/3 according umbilical artery present/absent/reversed end-diastolic blood flow, respectively. Cardiac function was assessed by modified-myocardial performance index, early-to-late diastolic filling ratios, cardiac output, and cord blood B-type natriuretic peptide; myocardial cell damage was assessed by heart fatty acid–binding protein, troponin-I, and high-sensitivity C-reactive protein.

Results - Modified-myocardial performance index, blood B-type natriuretic peptide, and early-to-late diastolic filling ratios were increased in a stage-dependent manner in IUGR fetuses, compared with appropriate-for-gestational-age fetuses. Heart fatty acid–binding protein levels were higher in IUGR fetuses at stage 3, compared with control fetuses. Cardiac output, troponin-I, and high-sensitivity C-reactive protein did not increase in IUGR fetuses at any stage.

Conclusion - IUGR fetuses showed signs of cardiac dysfunction from early stages. Cardiac dysfunction deteriorates further with the progression of fetal compromise, together with the appearance of biochemical signs of cell damage.

Original language	English
Pages (from-to)	254.e1-254.e8
Number of pages	8
Journal	American Journal of Obstetrics and Gynecology
Volume	199
Issue number	3
DOIs	https://doi.org/10.1016/j.ajog.2008.06.056
Publication status	Published - Sept 2008
Event	28th Annual Meeting of the Society for Maternal–Fetal Medicine - Dallas (TX), United States Duration: 28 Jan 2008 → 2 Feb 2008

Keywords

cardiac function
Doppler ultrasound
heart fatty acid–binding protein
intrauterine growth restriction
myocardial damage

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10.1016/j.ajog.2008.06.056

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Crispi, F., Hernandez-Andrade, E., Pelsers, M. M. A. L., Plasencia, W., Benavides-Serralde, J. A., Eixarch, E., le Noble, F., Ahmed, A., Glatz, J. F. C., Nicolaides, K. H., & Gratacos, E. (2008). Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses. American Journal of Obstetrics and Gynecology, 199(3), 254.e1-254.e8. https://doi.org/10.1016/j.ajog.2008.06.056

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title = "Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses",

abstract = "Objective - The purpose of this study was to assess cardiac function and cell damage in intrauterine growth-restricted (IUGR) fetuses across clinical Doppler stages of deterioration.Study Design - One hundred twenty appropriate-for-gestational-age and 81 IUGR fetuses were classified in stages 1/2/3 according umbilical artery present/absent/reversed end-diastolic blood flow, respectively. Cardiac function was assessed by modified-myocardial performance index, early-to-late diastolic filling ratios, cardiac output, and cord blood B-type natriuretic peptide; myocardial cell damage was assessed by heart fatty acid–binding protein, troponin-I, and high-sensitivity C-reactive protein.Results - Modified-myocardial performance index, blood B-type natriuretic peptide, and early-to-late diastolic filling ratios were increased in a stage-dependent manner in IUGR fetuses, compared with appropriate-for-gestational-age fetuses. Heart fatty acid–binding protein levels were higher in IUGR fetuses at stage 3, compared with control fetuses. Cardiac output, troponin-I, and high-sensitivity C-reactive protein did not increase in IUGR fetuses at any stage.Conclusion - IUGR fetuses showed signs of cardiac dysfunction from early stages. Cardiac dysfunction deteriorates further with the progression of fetal compromise, together with the appearance of biochemical signs of cell damage.",

keywords = "cardiac function, Doppler ultrasound, heart fatty acid–binding protein, intrauterine growth restriction, myocardial damage",

author = "F{\`a}tima Crispi and Edgar Hernandez-Andrade and Pelsers, {Maurice M.A.L.} and Walter Plasencia and Benavides-Serralde, {Jesus Andres} and Elisenda Eixarch and {le Noble}, Ferdinand and Asif Ahmed and Glatz, {Jan F.C.} and Nicolaides, {Kypros H.} and Eduard Gratacos",

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month = sep,

doi = "10.1016/j.ajog.2008.06.056",

language = "English",

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pages = "254.e1--254.e8",

journal = "American Journal of Obstetrics and Gynecology",

issn = "0002-9378",

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number = "3",

note = "28th Annual Meeting of the Society for Maternal–Fetal Medicine ; Conference date: 28-01-2008 Through 02-02-2008",

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Crispi, F, Hernandez-Andrade, E, Pelsers, MMAL, Plasencia, W, Benavides-Serralde, JA, Eixarch, E, le Noble, F, Ahmed, A, Glatz, JFC, Nicolaides, KH & Gratacos, E 2008, 'Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses', American Journal of Obstetrics and Gynecology, vol. 199, no. 3, pp. 254.e1-254.e8. https://doi.org/10.1016/j.ajog.2008.06.056

TY - JOUR

T1 - Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses

AU - Crispi, Fàtima

AU - Hernandez-Andrade, Edgar

AU - Pelsers, Maurice M.A.L.

AU - Plasencia, Walter

AU - Benavides-Serralde, Jesus Andres

AU - Eixarch, Elisenda

AU - le Noble, Ferdinand

AU - Ahmed, Asif

AU - Glatz, Jan F.C.

AU - Nicolaides, Kypros H.

AU - Gratacos, Eduard

PY - 2008/9

Y1 - 2008/9

N2 - Objective - The purpose of this study was to assess cardiac function and cell damage in intrauterine growth-restricted (IUGR) fetuses across clinical Doppler stages of deterioration.Study Design - One hundred twenty appropriate-for-gestational-age and 81 IUGR fetuses were classified in stages 1/2/3 according umbilical artery present/absent/reversed end-diastolic blood flow, respectively. Cardiac function was assessed by modified-myocardial performance index, early-to-late diastolic filling ratios, cardiac output, and cord blood B-type natriuretic peptide; myocardial cell damage was assessed by heart fatty acid–binding protein, troponin-I, and high-sensitivity C-reactive protein.Results - Modified-myocardial performance index, blood B-type natriuretic peptide, and early-to-late diastolic filling ratios were increased in a stage-dependent manner in IUGR fetuses, compared with appropriate-for-gestational-age fetuses. Heart fatty acid–binding protein levels were higher in IUGR fetuses at stage 3, compared with control fetuses. Cardiac output, troponin-I, and high-sensitivity C-reactive protein did not increase in IUGR fetuses at any stage.Conclusion - IUGR fetuses showed signs of cardiac dysfunction from early stages. Cardiac dysfunction deteriorates further with the progression of fetal compromise, together with the appearance of biochemical signs of cell damage.

AB - Objective - The purpose of this study was to assess cardiac function and cell damage in intrauterine growth-restricted (IUGR) fetuses across clinical Doppler stages of deterioration.Study Design - One hundred twenty appropriate-for-gestational-age and 81 IUGR fetuses were classified in stages 1/2/3 according umbilical artery present/absent/reversed end-diastolic blood flow, respectively. Cardiac function was assessed by modified-myocardial performance index, early-to-late diastolic filling ratios, cardiac output, and cord blood B-type natriuretic peptide; myocardial cell damage was assessed by heart fatty acid–binding protein, troponin-I, and high-sensitivity C-reactive protein.Results - Modified-myocardial performance index, blood B-type natriuretic peptide, and early-to-late diastolic filling ratios were increased in a stage-dependent manner in IUGR fetuses, compared with appropriate-for-gestational-age fetuses. Heart fatty acid–binding protein levels were higher in IUGR fetuses at stage 3, compared with control fetuses. Cardiac output, troponin-I, and high-sensitivity C-reactive protein did not increase in IUGR fetuses at any stage.Conclusion - IUGR fetuses showed signs of cardiac dysfunction from early stages. Cardiac dysfunction deteriorates further with the progression of fetal compromise, together with the appearance of biochemical signs of cell damage.

KW - cardiac function

KW - Doppler ultrasound

KW - heart fatty acid–binding protein

KW - intrauterine growth restriction

KW - myocardial damage

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U2 - 10.1016/j.ajog.2008.06.056

DO - 10.1016/j.ajog.2008.06.056

M3 - Article

C2 - 18771973

SN - 0002-9378

VL - 199

SP - 254.e1-254.e8

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

IS - 3

T2 - 28th Annual Meeting of the Society for Maternal–Fetal Medicine

Y2 - 28 January 2008 through 2 February 2008

ER -

Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses

Abstract

Keywords

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