Cardiorespiratory effects induced by vagus nerve stimulation in epileptic children

Mickael Pruvost; Boubker Zaaimi; Reinhard Grebe; Fabrice Wallois; Patrick Berquin; Volker Perlitz

doi:10.1007/s11517-006-0041-5

Cardiorespiratory effects induced by vagus nerve stimulation in epileptic children

Mickael Pruvost^*
, Boubker Zaaimi
, Reinhard Grebe
, Fabrice Wallois
, Patrick Berquin
, Volker Perlitz

^*Corresponding author for this work

College of Health and Life Sciences

University of Picardy
CHU Nord
Klinik für Psychosomatik und Psychotherapeutische Medizin

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Vagus nerve stimulation (VNS) is used in pharmaco-resistant epilepsy to decrease the number of seizures. Although it is well known that VNS affects respiration, there are only a few reports concerning an effect of VNS on heart rate or heart rate variability (HRV). We investigated the relationship between respiratory frequency and the high frequency (HF) domain of the discrete Fourier transform (DFT) of the RR interval function during night sleep recordings of ten subjects treated with VNS. Our results show that VNS shifts the frequency of maximal power spectrum density (PSD) in the HF-band, decreases the related PSD and induces a partial cardiorespiratory decoupling.

Original language	English
Pages (from-to)	338-347
Number of pages	10
Journal	Medical and Biological Engineering and Computing
Volume	44
Issue number	4
DOIs	https://doi.org/10.1007/s11517-006-0041-5
Publication status	Published - 1 Apr 2006

Funding

Acknowledgements We thank the technicians staff of University Hospital for the data recordings. This work was supported by Jules Verne University of Picardie, Regional University Hospital, Homme, Technologie Systèmes Complexes program (HTSC), Conseil Régional de Picardie, European Social Funds, Fondation pour l’Avenir and Cyberonics.

Keywords

Cardiorespiratory coupling
HRV
Vagus nerve stimulation

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10.1007/s11517-006-0041-5

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AU - Berquin, Patrick

AU - Perlitz, Volker

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AB - Vagus nerve stimulation (VNS) is used in pharmaco-resistant epilepsy to decrease the number of seizures. Although it is well known that VNS affects respiration, there are only a few reports concerning an effect of VNS on heart rate or heart rate variability (HRV). We investigated the relationship between respiratory frequency and the high frequency (HF) domain of the discrete Fourier transform (DFT) of the RR interval function during night sleep recordings of ten subjects treated with VNS. Our results show that VNS shifts the frequency of maximal power spectrum density (PSD) in the HF-band, decreases the related PSD and induces a partial cardiorespiratory decoupling.

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Cardiorespiratory effects induced by vagus nerve stimulation in epileptic children

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Keywords

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