Carnosine and cancer: a perspective

Frank Gaunitz*, Alan R. Hipkiss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma is discussed. Possible mechanisms by which carnosine may perform its anti-tumourigenic effects are outlined and its expected bioavailability and possible negative and positive side effects are considered. Finally, alternative strategies are examined such as treatment with other dipeptides or β-alanine.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalAmino Acids
Volume43
Issue number1
Early online date28 Mar 2012
DOIs
Publication statusPublished - 1 Jul 2012

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