Carnosine and cancer: a perspective

Frank Gaunitz; Alan R. Hipkiss

doi:10.1007/s00726-012-1271-5

Carnosine and cancer: a perspective

Frank Gaunitz^*
, Alan R. Hipkiss

^*Corresponding author for this work

School of Biosciences

Universitätsklinikum Leipzig AöR
Aston University

Research output: Contribution to journal › Article › peer-review

75 Citations (SciVal)

Abstract

The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma is discussed. Possible mechanisms by which carnosine may perform its anti-tumourigenic effects are outlined and its expected bioavailability and possible negative and positive side effects are considered. Finally, alternative strategies are examined such as treatment with other dipeptides or β-alanine.

Original language	English
Pages (from-to)	135-142
Number of pages	8
Journal	Amino Acids
Volume	43
Issue number	1
Early online date	28 Mar 2012
DOIs	https://doi.org/10.1007/s00726-012-1271-5
Publication status	Published - 1 Jul 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/s00726-012-1271-5

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AB - The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma is discussed. Possible mechanisms by which carnosine may perform its anti-tumourigenic effects are outlined and its expected bioavailability and possible negative and positive side effects are considered. Finally, alternative strategies are examined such as treatment with other dipeptides or β-alanine.

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Carnosine and cancer: a perspective

Abstract

UN SDGs

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