CCK2–Gastrin Antagonist: Development of PNB-001 (4-Chloro- 5-Hydroxy-1-Phenylethyl-5-Phenyl-1, 5-Dihydro-Pyrrol-2-one) as Anti-Inflammatory Analgesic

Keyphrases

• 5-phenyl-1 100%
• CCK2 100%
• Chloro 100%
• Isolated Tissue 100%
• Analgesic 100%
• Furfural 100%
• Tissue Preparation 100%
• Gastrin 100%
• Pyrrol-2-ones 100%
• Oral Administration 50%
• In(III) 50%
• IC50 50%
• Binding Assay 50%
• Lead Structure 50%
• Anxiolytic Activity 50%
• Receptor Binding Assay 50%
• Antagonism 50%
• In Vivo Evaluation 50%
• Morphine 50%
• Maze Test 50%
• Selective Ligands 50%
• Diazepam 50%
• Preclinical Development 50%
• Pain Management 50%
• Lead Molecules 50%
• Inflammatory Pain 50%
• Hot Plate 50%
• Analgesic Activity 50%
• Formalin Test 50%
• Tail Immersion Test 50%
• CCK2 Antagonist 50%
• Clinical Phases 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Anti-Inflammatory Drug 100%
• Analgesic Agent 100%
• Furfural 100%
• Cholecystokinin B Receptor Antagonist 100%
• IC50 50%
• Structure Activity Relationship 50%
• Cholecystokinin 50%
• Anxiolytic Activity 50%
• Ligand Binding Assay 50%
• Morphine 50%
• Diazepam 50%
• Gastrin 50%
• Inflammatory Pain 50%