Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer

Scott Palmer, Karina Litvinova, Andrey Dunaev, Stewart Fleming, David McGloin, Ghulam Nabi

Research output: Contribution to journalArticle

Abstract

Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients.

Original languageEnglish
Pages (from-to)1193-1201
Number of pages9
JournalBiomedical Optics Express
Volume7
Issue number4
Early online date1 Mar 2016
DOIs
Publication statusPublished - 7 Mar 2016

Bibliographical note

Published by The Optical Society under the terms of the Creative Commons
Attribution 4.0 License . Further distribution of this work must maintain attribution
to the author(s) and the published article’s title, journal citation, and DOI.

Funding: EU FP7 (project ABLADE grant 324370); studentship from NHS and EPSRC (grant number EP/K503010/1); state task of the Ministry of Education and Science, Russian Federation, for the State University – Education-Science-Production Complex (basic part, No 310)

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