Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue

Qi-Zhi Chen, Alexander Bismarck, Ulrich Hansen, Junaid Sarah, Michael Q Tran, Siân E Harding, Nadire N Ali, Aldo R Boccaccini

Research output: Contribution to journalArticlepeer-review

Abstract

The myocardial tissue lacks significant intrinsic regenerative capability to replace the lost cells. Therefore, the heart is a major target of research within the field of tissue engineering, which aims to replace infarcted myocardium and enhance cardiac function. The primary objective of this work was to develop a biocompatible, degradable and superelastic heart patch from poly(glycerol sebacate) (PGS). PGS was synthesised at 110, 120 and 130 degrees C by polycondensation of glycerol and sebacic acid with a mole ratio of 1:1. The investigation was focused on the mechanical and biodegrading behaviours of the developed PGS. PGS materials synthesised at 110, 120 and 130 degrees C have Young's moduli of 0.056, 0.22 and 1.2 MPa, respectively, which satisfy the mechanical requirements on the materials applied for the heart patch and 3D myocardial tissue engineering construction. Degradation assessment in phosphate buffered saline and Knockout DMEM culture medium has demonstrated that the PGS has a wide range of degradability, from being degradable in a couple of weeks to being nearly inert. The matching of physical characteristics to those of the heart, the ability to fine tune degradation rates in biologically relevant media and initial data showing biocompatibility indicate that this material has promise for cardiac tissue engineering applications.

Original languageEnglish
Pages (from-to)47-57
Number of pages11
JournalBiomaterials
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Cross-Linking Reagents
  • Decanoates
  • Elastomers
  • Furans
  • Glycerol
  • Microscopy, Electron, Scanning
  • Myocardium
  • Polymers
  • Stress, Mechanical
  • Tensile Strength
  • Tissue Engineering
  • X-Ray Diffraction

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