Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I)

Natalya A. Vorotnikova, Olga A. Efremova, Alphiya R. Tsygankova, Konstantin A. Brylev, Mariya V. Edeleva, Olga G. Kurskaya, Andrew J. Sutherland, Alexandr M. Shestopalov, Yuri V. Mironov, Michael A. Shestopalov*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Halide octahedral molybdenum clusters [(Mo6X8)L6]n- possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol-modified polystyrene microbeads (PS-SH) doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of (Mo6I8)@PS-SH is significantly higher (0.04) than that of (Mo6Cl8)@PS-SH (6Br8)@PS-SH (6X8)@PS-SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells.

Original languageEnglish
Number of pages7
JournalPolymers for Advanced Technologies
VolumeEarly view
Early online date11 Jan 2016
DOIs
Publication statusE-pub ahead of print - 11 Jan 2016

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Bibliographical note

This is the peer reviewed version of the following article: Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., ... Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I). Polymers for advanced technologies, Early view., which has been published in final form at http://dx.doi.org/10.1002/pat.3749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Funding: Russian Science Foundation (14-14-00192); Royal Society (IE140281); and FP7 Marie Curie Inter-European Fellowship (327440)

Keywords

  • cytotoxicity
  • molybdenum cluster complex
  • photoluminescence
  • polystyrene microbeads

Cite this

Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., Sutherland, A. J., Shestopalov, A. M., Mironov, Y. V., & Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I). Polymers for Advanced Technologies, Early view. https://doi.org/10.1002/pat.3749