Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I)

Natalya A. Vorotnikova; Olga A. Efremova; Alphiya R. Tsygankova; Konstantin A. Brylev; Mariya V. Edeleva; Olga G. Kurskaya; Andrew J. Sutherland; Alexandr M. Shestopalov; Yuri V. Mironov; Michael A. Shestopalov

doi:10.1002/pat.3749

Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo₆X₈)(NO₃)₆]^2- (X=Cl, Br, I)

Natalya A. Vorotnikova
, Olga A. Efremova
, Alphiya R. Tsygankova
, Konstantin A. Brylev
, Mariya V. Edeleva
, Olga G. Kurskaya
, Andrew J. Sutherland
, Alexandr M. Shestopalov
, Yuri V. Mironov
, Michael A. Shestopalov^*

^*Corresponding author for this work

University of Hull
Research Institute of Experimental and Clinical Medicine
Scientific Institute of Clinical and Experimental Lymphology
Novosibirsk State University
Novosibirsk Institute of Organic Chemistry SB RAS
Nikolaev Institute of Inorganic Chemistry SB RAS

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

134 Downloads (Pure)

Abstract

Halide octahedral molybdenum clusters [(Mo₆X₈)L₆]^n- possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol-modified polystyrene microbeads (PS-SH) doped with [(Mo₆X₈)(NO₃)₆]^2- (X=Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of (Mo₆I₈)@PS-SH is significantly higher (0.04) than that of (Mo₆Cl₈)@PS-SH (6Br₈)@PS-SH (6X₈)@PS-SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells.

Original language	English
Pages (from-to)	922– 928
Number of pages	7
Journal	Polymers for Advanced Technologies
Volume	27
Issue number	7
Early online date	11 Jan 2016
DOIs	https://doi.org/10.1002/pat.3749
Publication status	Published - 13 Jun 2016

Bibliographical note

This is the peer reviewed version of the following article: Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., ... Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I). Polymers for advanced technologies, Early view., which has been published in final form at http://dx.doi.org/10.1002/pat.3749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Funding: Russian Science Foundation (14-14-00192); Royal Society (IE140281); and FP7 Marie Curie Inter-European Fellowship (327440)

Keywords

cytotoxicity
molybdenum cluster complex
photoluminescence
polystyrene microbeads

Access to Document

10.1002/pat.3749

Characterisation and cytotoxicity studies of thiol-modified polystyrene microbeads
This is the peer reviewed version of the following article: Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., ... Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I). Polymers for advanced technologies, Early view., which has been published in final form at http://dx.doi.org/10.1002/pat.3749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 0.98 MB

Cite this

Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., Sutherland, A. J., Shestopalov, A. M., Mironov, Y. V., & Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo₆X₈)(NO₃)₆]^2- (X=Cl, Br, I). Polymers for Advanced Technologies, 27(7), 922– 928. https://doi.org/10.1002/pat.3749

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title = "Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I)",

abstract = "Halide octahedral molybdenum clusters [(Mo6X8)L6]n- possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol-modified polystyrene microbeads (PS-SH) doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of (Mo6I8)@PS-SH is significantly higher (0.04) than that of (Mo6Cl8)@PS-SH (6Br8)@PS-SH (6X8)@PS-SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells.",

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author = "Vorotnikova, \{Natalya A.\} and Efremova, \{Olga A.\} and Tsygankova, \{Alphiya R.\} and Brylev, \{Konstantin A.\} and Edeleva, \{Mariya V.\} and Kurskaya, \{Olga G.\} and Sutherland, \{Andrew J.\} and Shestopalov, \{Alexandr M.\} and Mironov, \{Yuri V.\} and Shestopalov, \{Michael A.\}",

note = "This is the peer reviewed version of the following article: Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., ... Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I). Polymers for advanced technologies, Early view., which has been published in final form at http://dx.doi.org/10.1002/pat.3749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Funding: Russian Science Foundation (14-14-00192); Royal Society (IE140281); and FP7 Marie Curie Inter-European Fellowship (327440)",

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Vorotnikova, NA, Efremova, OA, Tsygankova, AR, Brylev, KA, Edeleva, MV, Kurskaya, OG, Sutherland, AJ, Shestopalov, AM, Mironov, YV & Shestopalov, MA 2016, 'Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo₆X₈)(NO₃)₆]^2- (X=Cl, Br, I)', Polymers for Advanced Technologies, vol. 27, no. 7, pp. 922– 928. https://doi.org/10.1002/pat.3749

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T1 - Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I)

AU - Vorotnikova, Natalya A.

AU - Efremova, Olga A.

AU - Tsygankova, Alphiya R.

AU - Brylev, Konstantin A.

AU - Edeleva, Mariya V.

AU - Kurskaya, Olga G.

AU - Sutherland, Andrew J.

AU - Shestopalov, Alexandr M.

AU - Mironov, Yuri V.

AU - Shestopalov, Michael A.

N1 - This is the peer reviewed version of the following article: Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., ... Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I). Polymers for advanced technologies, Early view., which has been published in final form at http://dx.doi.org/10.1002/pat.3749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Funding: Russian Science Foundation (14-14-00192); Royal Society (IE140281); and FP7 Marie Curie Inter-European Fellowship (327440)

PY - 2016/6/13

Y1 - 2016/6/13

N2 - Halide octahedral molybdenum clusters [(Mo6X8)L6]n- possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol-modified polystyrene microbeads (PS-SH) doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of (Mo6I8)@PS-SH is significantly higher (0.04) than that of (Mo6Cl8)@PS-SH (6Br8)@PS-SH (6X8)@PS-SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells.

AB - Halide octahedral molybdenum clusters [(Mo6X8)L6]n- possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol-modified polystyrene microbeads (PS-SH) doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of (Mo6I8)@PS-SH is significantly higher (0.04) than that of (Mo6Cl8)@PS-SH (6Br8)@PS-SH (6X8)@PS-SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells.

KW - cytotoxicity

KW - molybdenum cluster complex

KW - photoluminescence

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