Chemical synthesis of oligonucleotides containing (M+4) guanine

Ruoling Guo; Qinguo Zheng

doi:10.1081/NCN-200059175

Chemical synthesis of oligonucleotides containing (M+4) guanine

Ruoling Guo
, Qinguo Zheng

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

HPLC MS/MS has shown great potential in the measurement of DNA oxidative damage. Its accuracy depends on the use of multiply isotopically labelled internal standards. In this report, multiply isotopically labelled (M + 4) guanine internal standards were prepared in the form of base, nucleoside, as well as DNA oligomer. To our knowledge, this is the first chemical synthesis of oligomers containing (M + 4) guanine, and we believe that they can be used to develop a procedure that can make further improvement to the existing analytical procedures. Copyright © Taylor & Francis, Inc.

Original language	English
Pages (from-to)	1081-1083
Number of pages	3
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	24
Issue number	5-7
DOIs	https://doi.org/10.1081/NCN-200059175
Publication status	Published - 2005

Bibliographical note

16th International Roundtable of the International Society for Nucleosides Nucleotides and Nucleic Acids (IS3NA), Minneapolis, MN (US), 12-16 September 2004

Keywords

DNA oxidative damage
internal standard
isotopically labelled guanine
oligonucleotide

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10.1081/NCN-200059175

Cite this

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title = "Chemical synthesis of oligonucleotides containing (M+4) guanine",

abstract = "HPLC MS/MS has shown great potential in the measurement of DNA oxidative damage. Its accuracy depends on the use of multiply isotopically labelled internal standards. In this report, multiply isotopically labelled (M + 4) guanine internal standards were prepared in the form of base, nucleoside, as well as DNA oligomer. To our knowledge, this is the first chemical synthesis of oligomers containing (M + 4) guanine, and we believe that they can be used to develop a procedure that can make further improvement to the existing analytical procedures. Copyright {\textcopyright} Taylor \& Francis, Inc.",

keywords = "DNA oxidative damage, internal standard, isotopically labelled guanine, oligonucleotide",

author = "Ruoling Guo and Qinguo Zheng",

note = "16th International Roundtable of the International Society for Nucleosides Nucleotides and Nucleic Acids (IS3NA), Minneapolis, MN (US), 12-16 September 2004",

year = "2005",

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AU - Zheng, Qinguo

N1 - 16th International Roundtable of the International Society for Nucleosides Nucleotides and Nucleic Acids (IS3NA), Minneapolis, MN (US), 12-16 September 2004

PY - 2005

Y1 - 2005

N2 - HPLC MS/MS has shown great potential in the measurement of DNA oxidative damage. Its accuracy depends on the use of multiply isotopically labelled internal standards. In this report, multiply isotopically labelled (M + 4) guanine internal standards were prepared in the form of base, nucleoside, as well as DNA oligomer. To our knowledge, this is the first chemical synthesis of oligomers containing (M + 4) guanine, and we believe that they can be used to develop a procedure that can make further improvement to the existing analytical procedures. Copyright © Taylor & Francis, Inc.

AB - HPLC MS/MS has shown great potential in the measurement of DNA oxidative damage. Its accuracy depends on the use of multiply isotopically labelled internal standards. In this report, multiply isotopically labelled (M + 4) guanine internal standards were prepared in the form of base, nucleoside, as well as DNA oligomer. To our knowledge, this is the first chemical synthesis of oligomers containing (M + 4) guanine, and we believe that they can be used to develop a procedure that can make further improvement to the existing analytical procedures. Copyright © Taylor & Francis, Inc.

KW - DNA oxidative damage

KW - internal standard

KW - isotopically labelled guanine

KW - oligonucleotide

UR - https://www.scopus.com/pages/publications/26644469873

UR - https://www.tandfonline.com/doi/abs/10.1081/NCN-200059175

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DO - 10.1081/NCN-200059175

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SN - 1525-7770

VL - 24

SP - 1081

EP - 1083

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-7

ER -

Chemical synthesis of oligonucleotides containing (M+4) guanine

Abstract

Bibliographical note

Keywords

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