Chronic administration of an aluminium-enriched diet impairs spatial orientation in a sub-group of C57BL6 female mice

D. Myers, Richard A. Armstrong, C.U.M. Smith

Research output: Contribution to conferencePoster

Abstract

Disturbances of spatial orientation are an early clinical component of senile dementia of the Alzheimer type (SDAT). since it has been suggested that an elevated aluminium intake associated with chronic nutritional deficiencies of calcium and magnesium may play an important role in the aetiology of SDAT, we have investigated the effect of such a dietary regime on the spatial orientation abilities of female C57BL6 mice using the Morris swimming pool test. Statistical analysis of the performances of control and experimental groups indicate that the ability to orientate towards a submerged and thus invisible platform is conistently and markedly impaired in the experimental group. The ability to orientate towards a visible platform is also significantly impaired although to a lesser extent. Analysis of the performances of individual animals demonstrate that this impairment of orientation in the experimental group only occurs in a sub-group of animals: the remainder display normal orientational ability.
Original languageEnglish
Publication statusPublished - 1988
Event6th International Meeting of the Brain Research Association - London
Duration: 28 Mar 198830 Mar 1988

Conference

Conference6th International Meeting of the Brain Research Association
CityLondon
Period28/03/8830/03/88

Fingerprint

Aptitude
Aluminum
Diet
Alzheimer Disease
Swimming Pools
Malnutrition
Magnesium
Calcium
Control Groups
Spatial Orientation

Bibliographical note

Abstract appearing in Abstracts of the sixth national meeting of the Brain Research Association. London (UK), 28-30 March 1988. Neurosci Lett Suppl. 1988;32:S43

Keywords

  • disturbances
  • spatial orientation
  • senile dementia
  • Alzheimer
  • aluminium intake
  • chronic nutritional deficiencies
  • calcium
  • magnesium
  • aetiology
  • Morris swimming pool test
  • orientational ability

Cite this

Myers, D., Armstrong, R. A., & Smith, C. U. M. (1988). Chronic administration of an aluminium-enriched diet impairs spatial orientation in a sub-group of C57BL6 female mice. Poster session presented at 6th International Meeting of the Brain Research Association, London, .
Myers, D. ; Armstrong, Richard A. ; Smith, C.U.M. / Chronic administration of an aluminium-enriched diet impairs spatial orientation in a sub-group of C57BL6 female mice. Poster session presented at 6th International Meeting of the Brain Research Association, London, .
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note = "Abstract appearing in Abstracts of the sixth national meeting of the Brain Research Association. London (UK), 28-30 March 1988. Neurosci Lett Suppl. 1988;32:S43; 6th International Meeting of the Brain Research Association ; Conference date: 28-03-1988 Through 30-03-1988",
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Myers, D, Armstrong, RA & Smith, CUM 1988, 'Chronic administration of an aluminium-enriched diet impairs spatial orientation in a sub-group of C57BL6 female mice' 6th International Meeting of the Brain Research Association, London, 28/03/88 - 30/03/88, .

Chronic administration of an aluminium-enriched diet impairs spatial orientation in a sub-group of C57BL6 female mice. / Myers, D.; Armstrong, Richard A.; Smith, C.U.M.

1988. Poster session presented at 6th International Meeting of the Brain Research Association, London, .

Research output: Contribution to conferencePoster

TY - CONF

T1 - Chronic administration of an aluminium-enriched diet impairs spatial orientation in a sub-group of C57BL6 female mice

AU - Myers, D.

AU - Armstrong, Richard A.

AU - Smith, C.U.M.

N1 - Abstract appearing in Abstracts of the sixth national meeting of the Brain Research Association. London (UK), 28-30 March 1988. Neurosci Lett Suppl. 1988;32:S43

PY - 1988

Y1 - 1988

N2 - Disturbances of spatial orientation are an early clinical component of senile dementia of the Alzheimer type (SDAT). since it has been suggested that an elevated aluminium intake associated with chronic nutritional deficiencies of calcium and magnesium may play an important role in the aetiology of SDAT, we have investigated the effect of such a dietary regime on the spatial orientation abilities of female C57BL6 mice using the Morris swimming pool test. Statistical analysis of the performances of control and experimental groups indicate that the ability to orientate towards a submerged and thus invisible platform is conistently and markedly impaired in the experimental group. The ability to orientate towards a visible platform is also significantly impaired although to a lesser extent. Analysis of the performances of individual animals demonstrate that this impairment of orientation in the experimental group only occurs in a sub-group of animals: the remainder display normal orientational ability.

AB - Disturbances of spatial orientation are an early clinical component of senile dementia of the Alzheimer type (SDAT). since it has been suggested that an elevated aluminium intake associated with chronic nutritional deficiencies of calcium and magnesium may play an important role in the aetiology of SDAT, we have investigated the effect of such a dietary regime on the spatial orientation abilities of female C57BL6 mice using the Morris swimming pool test. Statistical analysis of the performances of control and experimental groups indicate that the ability to orientate towards a submerged and thus invisible platform is conistently and markedly impaired in the experimental group. The ability to orientate towards a visible platform is also significantly impaired although to a lesser extent. Analysis of the performances of individual animals demonstrate that this impairment of orientation in the experimental group only occurs in a sub-group of animals: the remainder display normal orientational ability.

KW - disturbances

KW - spatial orientation

KW - senile dementia

KW - Alzheimer

KW - aluminium intake

KW - chronic nutritional deficiencies

KW - calcium

KW - magnesium

KW - aetiology

KW - Morris swimming pool test

KW - orientational ability

M3 - Poster

ER -

Myers D, Armstrong RA, Smith CUM. Chronic administration of an aluminium-enriched diet impairs spatial orientation in a sub-group of C57BL6 female mice. 1988. Poster session presented at 6th International Meeting of the Brain Research Association, London, .