Disturbances of spatial orientation are an early clinical component of senile dementia of the Alzheimer type (SDAT). since it has been suggested that an elevated aluminium intake associated with chronic nutritional deficiencies of calcium and magnesium may play an important role in the aetiology of SDAT, we have investigated the effect of such a dietary regime on the spatial orientation abilities of female C57BL6 mice using the Morris swimming pool test. Statistical analysis of the performances of control and experimental groups indicate that the ability to orientate towards a submerged and thus invisible platform is conistently and markedly impaired in the experimental group. The ability to orientate towards a visible platform is also significantly impaired although to a lesser extent. Analysis of the performances of individual animals demonstrate that this impairment of orientation in the experimental group only occurs in a sub-group of animals: the remainder display normal orientational ability.
|Publication status||Published - 1988|
|Event||6th International Meeting of the Brain Research Association - London|
Duration: 28 Mar 1988 → 30 Mar 1988
|Conference||6th International Meeting of the Brain Research Association|
|Period||28/03/88 → 30/03/88|
Bibliographical noteAbstract appearing in Abstracts of the sixth national meeting of the Brain Research Association. London (UK), 28-30 March 1988. Neurosci Lett Suppl. 1988;32:S43
- spatial orientation
- senile dementia
- aluminium intake
- chronic nutritional deficiencies
- Morris swimming pool test
- orientational ability
Myers, D., Armstrong, R. A., & Smith, C. U. M. (1988). Chronic administration of an aluminium-enriched diet impairs spatial orientation in a sub-group of C57BL6 female mice. Poster session presented at 6th International Meeting of the Brain Research Association, London, .