Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants.
Bibliographical note© 2012 Kelly et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Kelly, M. A., Rees, S. D., Hydrie, M. Z. I., Shera, A. S., Bellary, S., O'Hare, J. P., Kumar, S., Taheri, S., Basit, A., Barnett, A. H. (2012). Circadian gene variants and susceptibility to type 2 diabetes: a pilot study. PLoS ONE, 7(4), [e32670]. https://doi.org/10.1371/journal.pone.0032670