Circadian gene variants and susceptibility to type 2 diabetes: a pilot study

M. Ann Kelly, Simon D. Rees, M. Zafar I. Hydrie, A. Samad Shera, Srikanth Bellary, J. Paul O'Hare, Sudhesh Kumar, Shahrad Taheri, Abdul Basit, Anthony H. Barnett, ,

Research output: Contribution to journalArticlepeer-review


Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants.
Original languageEnglish
Article numbere32670
Number of pages7
JournalPLoS ONE
Issue number4
Publication statusPublished - 2 Apr 2012

Bibliographical note

© 2012 Kelly et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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