Circadian gene variants and susceptibility to type 2 diabetes: a pilot study

M. Ann Kelly; Simon D. Rees; M. Zafar I. Hydrie; A. Samad Shera; Srikanth Bellary; J. Paul O'Hare; Sudhesh Kumar; Shahrad Taheri; Abdul Basit; Anthony H. Barnett; DIAGRAM Consortium; SAT2D consortium

doi:10.1371/journal.pone.0032670

Circadian gene variants and susceptibility to type 2 diabetes: a pilot study

M. Ann Kelly, Simon D. Rees, M. Zafar I. Hydrie, A. Samad Shera, Srikanth Bellary, J. Paul O'Hare, Sudhesh Kumar, Shahrad Taheri, Abdul Basit, Anthony H. Barnett, DIAGRAM Consortium, SAT2D consortium

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Abstract

Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants.

Original language	English
Article number	e32670
Number of pages	7
Journal	PLoS ONE
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0032670
Publication status	Published - 2 Apr 2012

Bibliographical note

© 2012 Kelly et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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10.1371/journal.pone.0032670

Circadian Gene Variants and Susceptibility to Type 2 Diabetes
© 2012 Kelly et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 306 KBLicence: CC BY 3.0

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032670

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abstract = "Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants.",

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AU - Bellary, Srikanth

AU - O'Hare, J. Paul

AU - Kumar, Sudhesh

AU - Taheri, Shahrad

AU - Basit, Abdul

AU - Barnett, Anthony H.

AU - DIAGRAM Consortium

AU - SAT2D consortium

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Circadian gene variants and susceptibility to type 2 diabetes: a pilot study

Abstract

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