Clinical evaluation of the Macuscope macular pigment densitometer

Research output: Contribution to journalArticle

Abstract

Background/aims. The MacuScope uses a psychophysical technique called heterochromic flicker photometry to measure macular pigment optical density (MPOD). Our aim was to determine the measurement variability (noise) of the MacuScope. Methods. Thirty-eight normally sighted participants who ranged in age from 19 to 46 years (25.7±7.6 years) were recruited from staff and students of Aston University. Data were collected by two operators, HB and JA, in two sessions separated by 1 week in order to assess test repeatability and reproducibility. Results. The overall mean MPOD for the cohort was 0.47±0.14. There was a significant negative correlation between MacuScope MPOD readings and age (r=-0.368, p=0.023). Coefficients were 0.45 and 0.58 for repeatability, and 0.49 and 0.36 for reproducibility. For each pair of results, there was a significant positive correlation between mean and difference MPOD values. Conclusions. If MPOD is being monitored over time then any change less than 0.58 units should not be considered clinically significant as it is very likely to be due to instrument noise. The size of the coefficient appears to be positively correlated with MPOD.
LanguageEnglish
Pages328-331
Number of pages4
JournalBritish Journal of Ophthalmology
Volume94
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Noise
Photometry
Macular Pigment
Reading
Students

Bibliographical note

Copyright of BMJ Publishing Group.

Keywords

  • MacuScope
  • heterochromic flicker photometry
  • macular pigment optical density
  • measurement variability

Cite this

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title = "Clinical evaluation of the Macuscope macular pigment densitometer",
abstract = "Background/aims. The MacuScope uses a psychophysical technique called heterochromic flicker photometry to measure macular pigment optical density (MPOD). Our aim was to determine the measurement variability (noise) of the MacuScope. Methods. Thirty-eight normally sighted participants who ranged in age from 19 to 46 years (25.7±7.6 years) were recruited from staff and students of Aston University. Data were collected by two operators, HB and JA, in two sessions separated by 1 week in order to assess test repeatability and reproducibility. Results. The overall mean MPOD for the cohort was 0.47±0.14. There was a significant negative correlation between MacuScope MPOD readings and age (r=-0.368, p=0.023). Coefficients were 0.45 and 0.58 for repeatability, and 0.49 and 0.36 for reproducibility. For each pair of results, there was a significant positive correlation between mean and difference MPOD values. Conclusions. If MPOD is being monitored over time then any change less than 0.58 units should not be considered clinically significant as it is very likely to be due to instrument noise. The size of the coefficient appears to be positively correlated with MPOD.",
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Clinical evaluation of the Macuscope macular pigment densitometer. / Bartlett, Hannah E.; Acton, Jennifer H.; Eperjesi, Frank.

In: British Journal of Ophthalmology, Vol. 94, No. 3, 03.2010, p. 328-331.

Research output: Contribution to journalArticle

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