Clinical utility of intravitreal fluocinolone acetonide (Iluvien®) implant in the management of patients with chronic diabetic macular edema: a review of the current literature

Habiba Saedon*, Astha Anand, Yang C. Yit

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

The first-line therapy for patients with center-involving diabetic macular edema (DME) is with intravitreal anti-vascular endothelial growth factor (VEGF) agents, with or without adjunctive macular laser treatment. However, a significant proportion of patients have persistent and recurrent edema despite repeated anti-VEGF injections. The fluocinolone acetonide (FA) 190 μg intravitreal implant has been shown in pivotal clinical trials to be efficacious for the treatment of DME and has been approved in many countries for use in patients who have not responded to first-line therapy. In this report, we have collated the latest data from the increasing number of studies to illustrate the pattern of usage of the Iluvien FA implant for DME during the current anti-VEGF era. We have shown that there is now a wealth of published evidence from real-world studies to support the clinical utility of the FA implant in achieving further resolution of edema and improving visual acuity outcomes in this challenging group of patients.

Original languageEnglish
Pages (from-to)583-590
Number of pages8
JournalClinical Ophthalmology
Volume11
DOIs
Publication statusPublished - 27 Mar 2017

Fingerprint

Fluocinolone Acetonide
Macular Edema
Vascular Endothelial Growth Factor A
Edema
Therapeutics
Visual Acuity
Lasers
Clinical Trials
Injections

Bibliographical note

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Keywords

  • diabetic macular edema
  • fluocinolone acetonide
  • Iluvien

Cite this

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title = "Clinical utility of intravitreal fluocinolone acetonide (Iluvien{\circledR}) implant in the management of patients with chronic diabetic macular edema: a review of the current literature",
abstract = "The first-line therapy for patients with center-involving diabetic macular edema (DME) is with intravitreal anti-vascular endothelial growth factor (VEGF) agents, with or without adjunctive macular laser treatment. However, a significant proportion of patients have persistent and recurrent edema despite repeated anti-VEGF injections. The fluocinolone acetonide (FA) 190 μg intravitreal implant has been shown in pivotal clinical trials to be efficacious for the treatment of DME and has been approved in many countries for use in patients who have not responded to first-line therapy. In this report, we have collated the latest data from the increasing number of studies to illustrate the pattern of usage of the Iluvien FA implant for DME during the current anti-VEGF era. We have shown that there is now a wealth of published evidence from real-world studies to support the clinical utility of the FA implant in achieving further resolution of edema and improving visual acuity outcomes in this challenging group of patients.",
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Clinical utility of intravitreal fluocinolone acetonide (Iluvien®) implant in the management of patients with chronic diabetic macular edema : a review of the current literature. / Saedon, Habiba; Anand, Astha; Yit, Yang C.

In: Clinical Ophthalmology, Vol. 11, 27.03.2017, p. 583-590.

Research output: Contribution to journalReview article

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PY - 2017/3/27

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