Close contact fluctuations: the seeding of signalling domains in the immunological synapse

Amit K. Chattopadhyay, Nigel J. Burroughs

Research output: Contribution to journalArticle

Abstract

We analyse the size and density of thermally induced regions of close contact in cell : cell contact interfaces within a harmonic potential approximation, estimating these regions to be below one-tenth of a micron across. Our calculations indicate that as the distance between the close contact threshold depth and the mean membrane-membrane separation increases, the density of close contact patches decreases exponentially while there is only a minimal variation in their mean size. The technique developed can be used to calculate the probability of first crossing in reflection symmetry violating systems. © Europhysics Letters Association.
Original languageEnglish
Article number48003
Number of pages5
JournalEurophysics Letters
Volume77
Issue number4
DOIs
Publication statusPublished - 5 Feb 2007

Bibliographical note

© EPLA, 2007

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