Clustering of Pick bodies in patients with Pick's disease

Richard A. Armstrong*, Nigel J. Cairns, Peter L. Lantos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Clustering of Pick bodies (PB) was studied in the frontal and temporal lobe in 10 cases of Pick's disease (PD). Pick bodies exhibited clustering in 47/50 (94%) brain areas analysed. In 20/50 (40%) brain areas, PB were present in a single large cluster ≤ 6400 μm in diameter, in 27/50 (54%) PB occurred in smaller clusters (200-3200 μm in diameter) which exhibited a regular periodicity relative to the tissue boundary, in 1/50 (2%) there was a regular distribution of individual PB and in 2/50 (4%), PB were randomly distributed. Mean cluster size of the PB was greater in the dentate gyrus compared with the inferior temporal gyrus and lateral occipitotemporal gyrus. Mean cluster size of PB in a brain region was positively correlated with the mean density of PB. Hence, PB exhibit essentially the same spatial patterns as senile plaques and neurofibrillary tangles in Alzheimer's disease (AD) and Lewy bodies in Dementia with Lewy bodies (DLB).

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 13 Feb 1998


  • Alzheimer's disease
  • clustering
  • frontal cortex
  • Pick body
  • Pick's disease
  • temporal lobe


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