Cognitive impairments in inherited metabolic diseases

Promises and challenges

Research output: Contribution to journalEditorial

Abstract

This is an introduction to the special issue on cognitive impairments in inherited metabolic diseases (IMD). It provides an overview of the studies included, focusing on the possibility of selective impairments which could provide unique evidence on the specificity of neural circuitries mediating cognitive functions. It will suggest that these circuitries have different metabolic properties which make them especially apt to carry out certain functions, but also particularly susceptible to certain forms of metabolic disruption. Knowledge of selective impairments is also crucial to properly evaluate the difficulties engendered by individual diseases and track treatment outcomes. IMR research holds the promise of a more complete understanding of cognition, from cellular functioning to behaviour and of further improvements in treatment. Advances, however, will require detailed assessments, comparisons across diseases, and the integration of different levels of explanation. This will be possible only through close collaborations between centres and types of professionals.
Original languageEnglish
Pages (from-to)113-119
JournalCognitive Neuropsychology
Volume35
Issue number3-4
DOIs
Publication statusPublished - 9 May 2018

Fingerprint

Metabolic Diseases
Cognition
Research
Cognitive Dysfunction
Cognitive Impairment
Impairment

Keywords

  • Metabolic impairments
  • cognitive impairments
  • specific impairments

Cite this

@article{9d88a61b075a4b28ab2c48f7d075fa1a,
title = "Cognitive impairments in inherited metabolic diseases: Promises and challenges",
abstract = "This is an introduction to the special issue on cognitive impairments in inherited metabolic diseases (IMD). It provides an overview of the studies included, focusing on the possibility of selective impairments which could provide unique evidence on the specificity of neural circuitries mediating cognitive functions. It will suggest that these circuitries have different metabolic properties which make them especially apt to carry out certain functions, but also particularly susceptible to certain forms of metabolic disruption. Knowledge of selective impairments is also crucial to properly evaluate the difficulties engendered by individual diseases and track treatment outcomes. IMR research holds the promise of a more complete understanding of cognition, from cellular functioning to behaviour and of further improvements in treatment. Advances, however, will require detailed assessments, comparisons across diseases, and the integration of different levels of explanation. This will be possible only through close collaborations between centres and types of professionals.",
keywords = "Metabolic impairments, cognitive impairments, specific impairments",
author = "Cristina Romani",
year = "2018",
month = "5",
day = "9",
doi = "10.1080/02643294.2017.1417249",
language = "English",
volume = "35",
pages = "113--119",
journal = "Cognitive Neuropsychology",
issn = "0264-3294",
publisher = "Psychology Press",
number = "3-4",

}

Cognitive impairments in inherited metabolic diseases : Promises and challenges. / Romani, Cristina.

In: Cognitive Neuropsychology, Vol. 35, No. 3-4, 09.05.2018, p. 113-119.

Research output: Contribution to journalEditorial

TY - JOUR

T1 - Cognitive impairments in inherited metabolic diseases

T2 - Promises and challenges

AU - Romani, Cristina

PY - 2018/5/9

Y1 - 2018/5/9

N2 - This is an introduction to the special issue on cognitive impairments in inherited metabolic diseases (IMD). It provides an overview of the studies included, focusing on the possibility of selective impairments which could provide unique evidence on the specificity of neural circuitries mediating cognitive functions. It will suggest that these circuitries have different metabolic properties which make them especially apt to carry out certain functions, but also particularly susceptible to certain forms of metabolic disruption. Knowledge of selective impairments is also crucial to properly evaluate the difficulties engendered by individual diseases and track treatment outcomes. IMR research holds the promise of a more complete understanding of cognition, from cellular functioning to behaviour and of further improvements in treatment. Advances, however, will require detailed assessments, comparisons across diseases, and the integration of different levels of explanation. This will be possible only through close collaborations between centres and types of professionals.

AB - This is an introduction to the special issue on cognitive impairments in inherited metabolic diseases (IMD). It provides an overview of the studies included, focusing on the possibility of selective impairments which could provide unique evidence on the specificity of neural circuitries mediating cognitive functions. It will suggest that these circuitries have different metabolic properties which make them especially apt to carry out certain functions, but also particularly susceptible to certain forms of metabolic disruption. Knowledge of selective impairments is also crucial to properly evaluate the difficulties engendered by individual diseases and track treatment outcomes. IMR research holds the promise of a more complete understanding of cognition, from cellular functioning to behaviour and of further improvements in treatment. Advances, however, will require detailed assessments, comparisons across diseases, and the integration of different levels of explanation. This will be possible only through close collaborations between centres and types of professionals.

KW - Metabolic impairments

KW - cognitive impairments

KW - specific impairments

UR - https://www.tandfonline.com/doi/full/10.1080/02643294.2017.1417249

U2 - 10.1080/02643294.2017.1417249

DO - 10.1080/02643294.2017.1417249

M3 - Editorial

VL - 35

SP - 113

EP - 119

JO - Cognitive Neuropsychology

JF - Cognitive Neuropsychology

SN - 0264-3294

IS - 3-4

ER -