Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

Deyan Ivanov; Viktor Dremin; Alexander Bykov; Ekaterina Borisova; Tsanislava Genova; Alexey Popov; Razvigor Ossikovski; Tatiana Novikova; Igor Meglinski

doi:10.1002/jbio.202000082

Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

Deyan Ivanov, Viktor Dremin, Alexander Bykov, Ekaterina Borisova, Tsanislava Genova, Alexey Popov, Razvigor Ossikovski, Tatiana Novikova, Igor Meglinski

Mechanical, Biomedical & Design Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincaré sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for noninvasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumor removal of G2-adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set-up, using supercontinuous fiber laser with irradiation fixed at 635 nm. We apply the Poincaré sphere and two-dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic approach.

Original language	English
Article number	e202000082
Journal	Journal of Biophotonics
Volume	13
Issue number	8
Early online date	10 May 2020
DOIs	https://doi.org/10.1002/jbio.202000082
Publication status	Published - 1 Aug 2020

Bibliographical note

This is the peer reviewed version of the following article: Ivanov, D., Dremin, V., Bykov, A., Borisova, E., Genova, T., Popov, A., Ossikovski, R., Novikova, T. and Meglinski, I. (2020), Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples. J. Biophotonics. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/jbio.202000082 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

Keywords

Poincaré sphere
colon cancer
polarimetric mapping
stokes polarimetry
tissue diagnostics

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10.1002/jbio.202000082

Colon cancer detection by using Poincaré sphere
This is the peer reviewed version of the following article: Ivanov, D., Dremin, V., Bykov, A., Borisova, E., Genova, T., Popov, A., Ossikovski, R., Novikova, T. and Meglinski, I. (2020), Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples. J. Biophotonics. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/jbio.202000082 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Accepted author manuscript, 1.97 MB

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title = "Colon cancer detection by using Poincar{\'e} sphere and 2D polarimetric mapping of ex vivo colon samples",

abstract = "This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincar{\'e} sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for noninvasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumor removal of G2-adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set-up, using supercontinuous fiber laser with irradiation fixed at 635 nm. We apply the Poincar{\'e} sphere and two-dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic approach.",

keywords = "Poincar{\'e} sphere, colon cancer, polarimetric mapping, stokes polarimetry, tissue diagnostics",

author = "Deyan Ivanov and Viktor Dremin and Alexander Bykov and Ekaterina Borisova and Tsanislava Genova and Alexey Popov and Razvigor Ossikovski and Tatiana Novikova and Igor Meglinski",

note = "This is the peer reviewed version of the following article: Ivanov, D., Dremin, V., Bykov, A., Borisova, E., Genova, T., Popov, A., Ossikovski, R., Novikova, T. and Meglinski, I. (2020), Colon cancer detection by using Poincar{\'e} sphere and 2D polarimetric mapping of ex vivo colon samples. J. Biophotonics. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/jbio.202000082 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.",

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AU - Dremin, Viktor

AU - Bykov, Alexander

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AU - Genova, Tsanislava

AU - Popov, Alexey

AU - Ossikovski, Razvigor

AU - Novikova, Tatiana

AU - Meglinski, Igor

N1 - This is the peer reviewed version of the following article: Ivanov, D., Dremin, V., Bykov, A., Borisova, E., Genova, T., Popov, A., Ossikovski, R., Novikova, T. and Meglinski, I. (2020), Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples. J. Biophotonics. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/jbio.202000082 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincaré sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for noninvasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumor removal of G2-adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set-up, using supercontinuous fiber laser with irradiation fixed at 635 nm. We apply the Poincaré sphere and two-dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic approach.

AB - This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincaré sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for noninvasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumor removal of G2-adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set-up, using supercontinuous fiber laser with irradiation fixed at 635 nm. We apply the Poincaré sphere and two-dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic approach.

KW - Poincaré sphere

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KW - polarimetric mapping

KW - stokes polarimetry

KW - tissue diagnostics

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ER -

Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

Abstract

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