Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

Deyan Ivanov, Viktor Dremin, Alexander Bykov, Ekaterina Borisova, Tsanislava Genova, Alexey Popov, Razvigor Ossikovski, Tatiana Novikova, Igor Meglinski

Research output: Contribution to journalArticle

Abstract

This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincaré sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for noninvasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumor removal of G2-adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set-up, using supercontinuous fiber laser with irradiation fixed at 635 nm. We apply the Poincaré sphere and two-dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic approach.

Original languageEnglish
Article numbere202000082
JournalJournal of Biophotonics
Volume13
Issue number8
Early online date10 May 2020
DOIs
Publication statusPublished - 1 Aug 2020

Bibliographical note

This is the peer reviewed version of the following article: Ivanov, D., Dremin, V., Bykov, A., Borisova, E., Genova, T., Popov, A., Ossikovski, R., Novikova, T. and Meglinski, I. (2020), Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples. J. Biophotonics. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/jbio.202000082  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

Keywords

  • Poincaré sphere
  • colon cancer
  • polarimetric mapping
  • stokes polarimetry
  • tissue diagnostics

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    Ivanov, D., Dremin, V., Bykov, A., Borisova, E., Genova, T., Popov, A., Ossikovski, R., Novikova, T., & Meglinski, I. (2020). Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples. Journal of Biophotonics, 13(8), [e202000082]. https://doi.org/10.1002/jbio.202000082