Colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration

Antonio Calcagni, Olivia Howells, Frank Eperjesi, Hannah Bartlett, Alastair Ko Denniston, Jonathan M Gibson, Christopher R Hogg, Timothy D Matthews

Research output: Contribution to journalArticle

Abstract

Purpose:
To generate the first published reference database of colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration and to explore this important feature in quality of vision.

Background:
Quality of vision depends on many factors. Changes in chromatic contrast sensitivity remain largely unexplored in eyes at high risk of neovascular age-related macular degeneration; they may however not only be relevant for quality of life but also an early indicator of the onset of the disease, so it is important to have a means to evaluate any variation in colour contrast sensitivity, especially in view of the likely increase in neovascular age-related macular degeneration as the population ages.

Methods:
This prospective longitudinal study evaluated colour contrast sensitivity along the protan and tritan colour axes in 145 eyes at high risk of neovascular age-related macular degeneration.

Results:
Colour contrast sensitivity showed statistically significant correlations with age and visual acuity, but not gender nor laterality (i.e. whether the right or left eye was being tested). There was significant variability among individuals, especially for the tritan axis, with some subjects well within normal limits for age and others with very poor colour contrast sensitivity.

Conclusion:
This study has generated the first published colour contrast sensitivity reference database for eyes at high risk of neovascular age-related macular degeneration. It has also shown a high inter-individual variability of colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration, but the significance of this is unclear. Further work is required to establish if eyes with high colour contrast sensitivity thresholds (i.e. poor colour vision) have a higher risk of developing neovascular age-related macular degeneration over time, and this is the subject of ongoing work.
Original languageEnglish
JournalEuropean Journal of Ophthalmology
Early online date14 Aug 2019
DOIs
Publication statusE-pub ahead of print - 14 Aug 2019

Fingerprint

Contrast Sensitivity
Macular Degeneration
Color
Databases
Color Vision
Visual Acuity
Longitudinal Studies
Quality of Life
Prospective Studies

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Funding: Dunhill Medical Trust (Grant number R304/0713).

Keywords

  • Age-related macular degeneration
  • ChromaTest
  • colour vision
  • contrast sensitivity
  • psychophysics

Cite this

Calcagni, Antonio ; Howells, Olivia ; Eperjesi, Frank ; Bartlett, Hannah ; Denniston, Alastair Ko ; Gibson, Jonathan M ; Hogg, Christopher R ; Matthews, Timothy D. / Colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration. In: European Journal of Ophthalmology. 2019.
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Colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration. / Calcagni, Antonio; Howells, Olivia; Eperjesi, Frank; Bartlett, Hannah; Denniston, Alastair Ko; Gibson, Jonathan M; Hogg, Christopher R; Matthews, Timothy D.

In: European Journal of Ophthalmology, 14.08.2019.

Research output: Contribution to journalArticle

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AU - Howells, Olivia

AU - Eperjesi, Frank

AU - Bartlett, Hannah

AU - Denniston, Alastair Ko

AU - Gibson, Jonathan M

AU - Hogg, Christopher R

AU - Matthews, Timothy D

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N2 - Purpose:To generate the first published reference database of colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration and to explore this important feature in quality of vision.Background:Quality of vision depends on many factors. Changes in chromatic contrast sensitivity remain largely unexplored in eyes at high risk of neovascular age-related macular degeneration; they may however not only be relevant for quality of life but also an early indicator of the onset of the disease, so it is important to have a means to evaluate any variation in colour contrast sensitivity, especially in view of the likely increase in neovascular age-related macular degeneration as the population ages.Methods:This prospective longitudinal study evaluated colour contrast sensitivity along the protan and tritan colour axes in 145 eyes at high risk of neovascular age-related macular degeneration.Results:Colour contrast sensitivity showed statistically significant correlations with age and visual acuity, but not gender nor laterality (i.e. whether the right or left eye was being tested). There was significant variability among individuals, especially for the tritan axis, with some subjects well within normal limits for age and others with very poor colour contrast sensitivity.Conclusion:This study has generated the first published colour contrast sensitivity reference database for eyes at high risk of neovascular age-related macular degeneration. It has also shown a high inter-individual variability of colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration, but the significance of this is unclear. Further work is required to establish if eyes with high colour contrast sensitivity thresholds (i.e. poor colour vision) have a higher risk of developing neovascular age-related macular degeneration over time, and this is the subject of ongoing work.

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