Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here we consider apoptotic cell-derived extracellular vesicles (ACdEV) and the role of contained lipids and lipid mediators in ensuring effective control of inflammation. We discuss key outstanding issues in the study of cell death and cell communication, and introduce the concept of the ‘active extracellular vesicle’ as a metabolically-active and potentially changing intercellular communicator.
Bibliographical note© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Communicating with the dead: lipids, lipid mediators and extracellular vesicles
Andrew Devitt, Helen R. Griffiths, Ivana MilicBiochemical Society Transactions May 2018, BST20160477; DOI: 10.1042/BST20160477
Funding: BBSRC grant (56253)