Communicating with the dead: lipids, lipid mediators and extracellular vesicle

Andrew Devitt, H.R. Griffiths⁎, Ivana Milic

Research output: Contribution to journalReview article

Abstract

Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here we consider apoptotic cell-derived extracellular vesicles (ACdEV) and the role of contained lipids and lipid mediators in ensuring effective control of inflammation. We discuss key outstanding issues in the study of cell death and cell communication, and introduce the concept of the ‘active extracellular vesicle’ as a metabolically-active and potentially changing intercellular communicator.
LanguageEnglish
Pages631-639
JournalBiochemical Society Transactions
Volume46
Issue number3
Early online date9 May 2018
DOIs
Publication statusPublished - May 2018

Fingerprint

Lipids
Cell death
Inflammation
Cells
Phagocytes
Apoptosis
Cell Communication
Communication
Cell Death
Extracellular Vesicles

Bibliographical note

© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Communicating with the dead: lipids, lipid mediators and extracellular vesicles
Andrew Devitt, Helen R. Griffiths, Ivana MilicBiochemical Society Transactions May 2018, BST20160477; DOI: 10.1042/BST20160477

Funding: BBSRC grant (56253)

Cite this

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Communicating with the dead : lipids, lipid mediators and extracellular vesicle. / Devitt, Andrew; Griffiths⁎, H.R.; Milic, Ivana.

In: Biochemical Society Transactions, Vol. 46, No. 3, 05.2018, p. 631-639.

Research output: Contribution to journalReview article

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