Communicating with the dead:  lipids, lipid mediators and extracellular vesicle

Andrew Devitt; H.R. Griffiths⁎; Ivana Milic

doi:10.1042/BST20160477

Communicating with the dead: lipids, lipid mediators and extracellular vesicle

Andrew Devitt
, H.R. Griffiths⁎
, Ivana Milic

Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

133 Downloads (Pure)

Abstract

Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here we consider apoptotic cell-derived extracellular vesicles (ACdEV) and the role of contained lipids and lipid mediators in ensuring effective control of inflammation. We discuss key outstanding issues in the study of cell death and cell communication, and introduce the concept of the ‘active extracellular vesicle’ as a metabolically-active and potentially changing intercellular communicator.

Original language	English
Pages (from-to)	631-639
Journal	Biochemical Society Transactions
Volume	46
Issue number	3
Early online date	9 May 2018
DOIs	https://doi.org/10.1042/BST20160477
Publication status	Published - 9 May 2018

Bibliographical note

© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Communicating with the dead: lipids, lipid mediators and extracellular vesicles
Andrew Devitt, Helen R. Griffiths, Ivana MilicBiochemical Society Transactions May 2018, BST20160477; DOI: 10.1042/BST20160477

Funding: BBSRC grant (56253)

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10.1042/BST20160477

Devitt et al. Accepted Author Manuscript
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Communicating with the dead: lipids, lipid mediators and extracellular vesicles Andrew Devitt, Helen R. Griffiths, Ivana MilicBiochemical Society Transactions May 2018, BST20160477; DOI: 10.1042/BST20160477
Accepted author manuscript, 688 KB

Cite this

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abstract = "Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here we consider apoptotic cell-derived extracellular vesicles (ACdEV) and the role of contained lipids and lipid mediators in ensuring effective control of inflammation. We discuss key outstanding issues in the study of cell death and cell communication, and introduce the concept of the {\textquoteleft}active extracellular vesicle{\textquoteright} as a metabolically-active and potentially changing intercellular communicator. ",

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AB - Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here we consider apoptotic cell-derived extracellular vesicles (ACdEV) and the role of contained lipids and lipid mediators in ensuring effective control of inflammation. We discuss key outstanding issues in the study of cell death and cell communication, and introduce the concept of the ‘active extracellular vesicle’ as a metabolically-active and potentially changing intercellular communicator.

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EP - 639

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 3

ER -

Communicating with the dead: lipids, lipid mediators and extracellular vesicle

Abstract

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