Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy

Yusuf Rajabally; Majid Ghasemi

doi:10.1002/mus.26747

Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy

Yusuf Rajabally, Majid Ghasemi

College of Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: The comparative value and suitability of outcome measures are uncertain in chronic inflammatory demyelinating polyneuropathy (CIDP).

Methods: We studied 35 patients with CIDP using the Overall Neuropathy Limitation Scale (ONLS), the inflammatory Rasch-built Overall Disability Scale (I-RODS), and the Medical Research Council Sum Score (MRCSS).

Results: Significant associations were determined between initial deficit and ONLS score (P =.002) and MRCSS improvement (P =.001) but not I-RODS score. A strong inverse correlation was observed between disease duration and I-RODS score(P =.002) but not ONLS/MRCSS improvement. A strong association was observed between age ≤ 40 years and I-RODS score (P =.001) but not ONLS/MRCSS improvement. When minimum important differences were used, ONLS and I-RODS sensitivities were comparable (P =.19).

Discussion: Overall Neuropathy Limitation Scale and I-RODS are equally sensitive in identifying change. Ease of administration, better ability to detect improvement in severe disease, and greater amplitude responses throughout the disease and in older patients favor the ONLS. The I-RODS appears more useful in early disease/younger patients.

Original language	English
Pages (from-to)	182-186
Number of pages	6
Journal	Muscle and Nerve
Volume	61
Issue number	2
Early online date	25 Oct 2019
DOIs	https://doi.org/10.1002/mus.26747
Publication status	Published - Feb 2020

Bibliographical note

This is the peer reviewed version of the following article: Rajabally, Y. A. and Ghasemi, M. (2019), Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy. Muscle Nerve. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/mus.26747. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

Keywords

chronic inflammatory demyelinating polyneuropathy
disability
minimal important difference
outcome measures
sensitivity
suitability
value

Access to Document

10.1002/mus.26747

Comparative value and determinants of suitability of outcome
This is the peer reviewed version of the following article: Rajabally, Y. A. and Ghasemi, M. (2019), Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy. Muscle Nerve. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/mus.26747. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Accepted author manuscript, 227 KB

Cite this

@article{d7a84b1639434715929726602484c5f1,

title = "Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy",

abstract = "Introduction: The comparative value and suitability of outcome measures are uncertain in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: We studied 35 patients with CIDP using the Overall Neuropathy Limitation Scale (ONLS), the inflammatory Rasch-built Overall Disability Scale (I-RODS), and the Medical Research Council Sum Score (MRCSS). Results: Significant associations were determined between initial deficit and ONLS score (P =.002) and MRCSS improvement (P =.001) but not I-RODS score. A strong inverse correlation was observed between disease duration and I-RODS score(P =.002) but not ONLS/MRCSS improvement. A strong association was observed between age ≤ 40 years and I-RODS score (P =.001) but not ONLS/MRCSS improvement. When minimum important differences were used, ONLS and I-RODS sensitivities were comparable (P =.19). Discussion: Overall Neuropathy Limitation Scale and I-RODS are equally sensitive in identifying change. Ease of administration, better ability to detect improvement in severe disease, and greater amplitude responses throughout the disease and in older patients favor the ONLS. The I-RODS appears more useful in early disease/younger patients.",

keywords = "chronic inflammatory demyelinating polyneuropathy, disability, minimal important difference, outcome measures, sensitivity, suitability, value",

author = "Yusuf Rajabally and Majid Ghasemi",

note = "This is the peer reviewed version of the following article: Rajabally, Y. A. and Ghasemi, M. (2019), Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy. Muscle Nerve. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/mus.26747. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. ",

year = "2020",

month = feb,

doi = "10.1002/mus.26747",

language = "English",

volume = "61",

pages = "182--186",

journal = "Muscle and Nerve",

issn = "0148-639X",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy

AU - Rajabally, Yusuf

AU - Ghasemi , Majid

N1 - This is the peer reviewed version of the following article: Rajabally, Y. A. and Ghasemi, M. (2019), Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy. Muscle Nerve. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/mus.26747. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

PY - 2020/2

Y1 - 2020/2

N2 - Introduction: The comparative value and suitability of outcome measures are uncertain in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: We studied 35 patients with CIDP using the Overall Neuropathy Limitation Scale (ONLS), the inflammatory Rasch-built Overall Disability Scale (I-RODS), and the Medical Research Council Sum Score (MRCSS). Results: Significant associations were determined between initial deficit and ONLS score (P =.002) and MRCSS improvement (P =.001) but not I-RODS score. A strong inverse correlation was observed between disease duration and I-RODS score(P =.002) but not ONLS/MRCSS improvement. A strong association was observed between age ≤ 40 years and I-RODS score (P =.001) but not ONLS/MRCSS improvement. When minimum important differences were used, ONLS and I-RODS sensitivities were comparable (P =.19). Discussion: Overall Neuropathy Limitation Scale and I-RODS are equally sensitive in identifying change. Ease of administration, better ability to detect improvement in severe disease, and greater amplitude responses throughout the disease and in older patients favor the ONLS. The I-RODS appears more useful in early disease/younger patients.

AB - Introduction: The comparative value and suitability of outcome measures are uncertain in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: We studied 35 patients with CIDP using the Overall Neuropathy Limitation Scale (ONLS), the inflammatory Rasch-built Overall Disability Scale (I-RODS), and the Medical Research Council Sum Score (MRCSS). Results: Significant associations were determined between initial deficit and ONLS score (P =.002) and MRCSS improvement (P =.001) but not I-RODS score. A strong inverse correlation was observed between disease duration and I-RODS score(P =.002) but not ONLS/MRCSS improvement. A strong association was observed between age ≤ 40 years and I-RODS score (P =.001) but not ONLS/MRCSS improvement. When minimum important differences were used, ONLS and I-RODS sensitivities were comparable (P =.19). Discussion: Overall Neuropathy Limitation Scale and I-RODS are equally sensitive in identifying change. Ease of administration, better ability to detect improvement in severe disease, and greater amplitude responses throughout the disease and in older patients favor the ONLS. The I-RODS appears more useful in early disease/younger patients.

KW - chronic inflammatory demyelinating polyneuropathy

KW - disability

KW - minimal important difference

KW - outcome measures

KW - sensitivity

KW - suitability

KW - value

UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/mus.26747

UR - http://www.scopus.com/inward/record.url?scp=85074867125&partnerID=8YFLogxK

U2 - 10.1002/mus.26747

DO - 10.1002/mus.26747

M3 - Article

SN - 0148-639X

VL - 61

SP - 182

EP - 186

JO - Muscle and Nerve

JF - Muscle and Nerve

IS - 2

ER -

Comparative value and determinants of suitability of outcome measures in treated chronic inflammatory demyelinating polyneuropathy

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this