Complex Measurements of Fluorescence and Speckle Contrast in Laboratory Mice during Pancreas Ischemia Modeling

Valery Shupletsov, Ksenia Kandurova, Evgeniya Seryogina, Gennadii Piavchenko, Viktor Dremin, Andrian Mamoshin, Andrey Dunaev

Research output: Contribution to journalConference articlepeer-review

Abstract

The paper describes the experiment at pancreas ischemia model carried out by combining the methods of fluorescence spectroscopy and laser speckle contrast imaging in laboratory mice. The measurement was performed before and after ischemia to evaluate the relationship between the changes of blood flow and metabolic activity. The results showed high positive correlation between fluorescence intensity at excitation wavelength of 365 nm and speckle contrast. At the same time, 450 nm fluorescence intensity and speckle contrast showed high negative correlation as well as two kinds of fluorescence maxima. The proposed approach seems promising for further studies and future clinical testing.

Original languageEnglish
Article number1114001-212
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume11140
Publication statusPublished - 21 Apr 2019
EventBiomedical Imaging and Sensing Conference 2019, BISC 2019 - Yokohama, Japan
Duration: 22 Apr 201926 Apr 2019

Keywords

  • Fluorescence spectroscopy
  • Ischemia
  • Mice
  • Pancreas
  • Speckle contrast

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