Computational model of bladder tissue based on its measured optical properties

Ilya E. Rafailov*, Victor V. Dremin, Karina S. Litvinova, Andrey V. Dunaev, Sergei G. Sokolovski, Edik U. Rafailov

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Urinary bladder diseases are a common problem throughout the world and often difficult to accurately diagnose. Furthermore, they pose a heavy financial burden on health services. Urinary bladder tissue from male pigs was spectrophotometrically measured and the resulting data used to calculate the absorption, transmission, and reflectance parameters, along with the derived coefficients of scattering and absorption. These were employed to create a "generic" computational bladder model based on optical properties, simulating the propagation of photons through the tissue at different wavelengths. Using the Monte-Carlo method and fluorescence spectra of UV and blue excited wavelength, diagnostically important biomarkers were modeled. Additionally, the multifunctional noninvasive diagnostics system "LAKK-M" was used to gather fluorescence data to further provide essential comparisons. The ultimate goal of the study was to successfully simulate the effects of varying excited radiation wavelengths on bladder tissue to determine the effectiveness of photonics diagnostic devices. With increased accuracy, this model could be used to reliably aid in differentiating healthy and pathological tissues within the bladder and potentially other hollow organs.

Original languageEnglish
Article number025006
Number of pages7
JournalJournal of Biomedical Optics
Volume21
Issue number2
DOIs
Publication statusPublished - 15 Feb 2016

Bibliographical note

Ilya E. Rafailov ; Victor V. Dremin ; Karina S. Litvinova ; Andrey V. Dunaev ; Sergei G. Sokolovski, et al., "Computational model of bladder tissue based on its measured optical properties", J. Biomed. Opt. 21(2), 025006 (Feb 15, 2016).

Copyright 2016 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

http://dx.doi.org/10.1117/1.JBO.21.2.025006

Keywords

  • fluorescence spectroscopy
  • Monte-Carlo
  • optical properties
  • three-dimensional model
  • tissue
  • urinary bladder cancer

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