Abstract
Genome sequences from many organisms, including humans, have been completed, and high-throughput analyses have produced burgeoning volumes of 'omics' data. Bioinformatics is crucial for the management and analysis of such data and is increasingly used to accelerate progress in a wide variety of large-scale and object-specific functional analyses. Refined algorithms enable biotechnologists to follow 'computer-aided strategies' based on experiments driven by high-confidence predictions. In order to address compound problems, current efforts in immuno-informatics and reverse vaccinology are aimed at developing and tuning integrative approaches and user-friendly, automated bioinformatics environments. This will herald a move to 'computer-aided biotechnology': smart projects in which time-consuming and expensive large-scale experimental approaches are progressively replaced by prediction-driven investigations.
Original language | English |
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Pages (from-to) | 190-200 |
Number of pages | 11 |
Journal | Trends in Biotechnology |
Volume | 26 |
Issue number | 4 |
Early online date | 21 Feb 2008 |
DOIs | |
Publication status | Published - Apr 2008 |
Keywords
- allergy and immunology
- animals
- artificial intelligence
- biomedical engineering
- biotechnology
- computer-aided design
- database management systems
- genetic databases
- humans
- immunity
- active immunotherapy
- user-computer interface