Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications

Karina T. Wright; Wagih El Masri; Aheed Osman; Joy Chowdhury; William E.B. Johnson

doi:10.1002/stem.570

Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications

Karina T. Wright, Wagih El Masri, Aheed Osman, Joy Chowdhury, William E.B. Johnson

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Abstract

Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and MSCs might promote spinal cord repair following transplantation have been extensively investigated. The objective of this review is to discuss these mechanisms; we briefly consider the controversial topic of HSC and MSC transdifferentiation into central nervous system cells but focus on the neurotrophic, tissue sparing, and reparative action of MSC grafts in the context of the spinal cord injury (SCI) milieu. We then discuss some of the specific issues related to the translation of HSC and MSC therapies for patients with SCI and present a comprehensive critique of the current bone marrow cell clinical trials for the treatment of SCI to date.

Original language	English
Pages (from-to)	169-178
Number of pages	10
Journal	Stem cells
Volume	29
Issue number	2
DOIs	https://doi.org/10.1002/stem.570
Publication status	Published - Feb 2011

Keywords

animals
bone marrow
bone marrow transplantation
hematopoietic stem cell transplantation
humans
mesenchymal stem cell transplantation
spinal cord injuries
spinal cord regeneration

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10.1002/stem.570

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title = "Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications",

abstract = "Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and MSCs might promote spinal cord repair following transplantation have been extensively investigated. The objective of this review is to discuss these mechanisms; we briefly consider the controversial topic of HSC and MSC transdifferentiation into central nervous system cells but focus on the neurotrophic, tissue sparing, and reparative action of MSC grafts in the context of the spinal cord injury (SCI) milieu. We then discuss some of the specific issues related to the translation of HSC and MSC therapies for patients with SCI and present a comprehensive critique of the current bone marrow cell clinical trials for the treatment of SCI to date.",

keywords = "animals, bone marrow, bone marrow transplantation, hematopoietic stem cell transplantation, humans, mesenchymal stem cell transplantation, spinal cord injuries, spinal cord regeneration",

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AU - Chowdhury, Joy

AU - Johnson, William E.B.

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Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications

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Keywords

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