Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

Ben Mead, Ann Logan, Martin Berry, Wendy Leadbeater, Ben A. Scheven*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Dental pulp stem cells (DPSC) are neural crest-derived ecto-mesenchymal stem cells that can relatively easily and non-invasively be isolated from the dental pulp of extracted postnatal and adult teeth. Accumulating evidence suggests that DPSC have great promise as a cellular therapy for central nervous system (CNS) and retinal injury and disease. The mode of action by which DPSC confer therapeutic benefit may comprise multiple pathways, in particular, paracrine-mediated processes which involve a wide array of secreted trophic factors and is increasingly regarded as the principal predominant mechanism. In this concise review, we present the current evidence for the use of DPSC to repair CNS damage, including recent findings on retinal ganglion cell neuroprotection and regeneration in optic nerve injury and glaucoma. Stem Cells 2017;35:61–67.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalStem cells
Volume35
Issue number1
Early online date7 Jun 2016
DOIs
Publication statusPublished - 1 Dec 2016

Fingerprint

Dental Pulp
Cell- and Tissue-Based Therapy
Stem Cells
Central Nervous System
Optic Nerve Injuries
Nervous System Trauma
Retinal Diseases
Neural Stem Cells
Retinal Ganglion Cells
Neural Crest
Nervous System Diseases
Mesenchymal Stromal Cells
Glaucoma
Regeneration
Tooth
Therapeutics

Bibliographical note

This is the peer reviewed version of the following article: Mead, B. , Logan, A. , Berry, M. , Leadbeater, W. and Scheven, B. A. (2017), Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair. Stem Cells, 35: 61-67, which has been published in final form at https://doi.org/10.1002/stem.2398.  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

Keywords

  • CNS
  • Dental pulp stem cells
  • glaucoma
  • mesenchymal stem cells
  • nerve repair
  • neural regeneration
  • optic nerve
  • retinal ganglion cells

Cite this

Mead, Ben ; Logan, Ann ; Berry, Martin ; Leadbeater, Wendy ; Scheven, Ben A. / Concise Review : Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair. In: Stem cells. 2016 ; Vol. 35, No. 1. pp. 61-67.
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Concise Review : Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair. / Mead, Ben; Logan, Ann; Berry, Martin; Leadbeater, Wendy; Scheven, Ben A.

In: Stem cells, Vol. 35, No. 1, 01.12.2016, p. 61-67.

Research output: Contribution to journalReview article

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