Consumption of bilberries controls gingival inflammation

Cecilia Widén, Michael Coleman, Sladjana Critén, Pernilla Karlgren-Andersson, Stefan Renvert, G. Rutger Persson

Research output: Contribution to journalSpecial issue

Abstract

Bioactive molecules in berries may be helpful in reducing the risk of oral diseases. The aim of this study was to determine the effect of bilberry consumption on the outcome of a routine dental clinical parameter of inflammation, bleeding on probing (BOP), as well as the impact on selected biomarkers of inflammation, such as cytokines, in gingival crevicular fluid (GCF) in individuals with gingivitis. Study individuals who did not receive standard of care treatment were allocated to either a placebo group or to groups that consumed either 250 or 500 g bilberries daily over seven days. The placebo group consumed an inactive product (starch). A study group, receiving standard of care (debridement only) was also included to provide a reference to standard of care treatment outcome. Cytokine levels were assayed using the Luminex MagPix system. The mean reduction in BOP before and after consumption of test product over 1 week was 41% and 59% in the groups that consumed either 250 or 500 g of bilberries/day respectively, and was 31% in the placebo group, and 58% in the standard of care reference group. The analysis only showed a significantreduction in cytokine levels in the group that consumed 500 g of bilberries/day. A statistically significant reduction was observed for IL-1β (p = 0.025), IL-6 (p = 0.012) and VEGF (p = 0.017) in GCF samples in the group that consumed 500 g of bilberries daily. It appears that berry intake has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care.

LanguageEnglish
Pages10665-10673
Number of pages9
JournalInternational Journal of Molecular Sciences
Volume16
Issue number5
DOIs
Publication statusPublished - 11 May 2015

Fingerprint

Vaccinium myrtillus
Standard of Care
Inflammation
Gingival Crevicular Fluid
Gingivitis
Placebos
Cytokines
Fruit
Mouth Diseases
bleeding
Hemorrhage
Fluids
Biomarkers
Debridement
Starch
Vascular Endothelial Growth Factor A
Interleukin-6
Tooth
starches
biomarkers

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • bleeding
  • clinical study
  • cytokines
  • gingival crevicular fluid
  • human

Cite this

Widén, C., Coleman, M., Critén, S., Karlgren-Andersson, P., Renvert, S., & Persson, G. R. (2015). Consumption of bilberries controls gingival inflammation. International Journal of Molecular Sciences, 16(5), 10665-10673. https://doi.org/10.3390/ijms160510665
Widén, Cecilia ; Coleman, Michael ; Critén, Sladjana ; Karlgren-Andersson, Pernilla ; Renvert, Stefan ; Persson, G. Rutger. / Consumption of bilberries controls gingival inflammation. In: International Journal of Molecular Sciences. 2015 ; Vol. 16, No. 5. pp. 10665-10673.
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Widén, C, Coleman, M, Critén, S, Karlgren-Andersson, P, Renvert, S & Persson, GR 2015, 'Consumption of bilberries controls gingival inflammation' International Journal of Molecular Sciences, vol. 16, no. 5, pp. 10665-10673. https://doi.org/10.3390/ijms160510665

Consumption of bilberries controls gingival inflammation. / Widén, Cecilia; Coleman, Michael; Critén, Sladjana; Karlgren-Andersson, Pernilla; Renvert, Stefan; Persson, G. Rutger.

In: International Journal of Molecular Sciences, Vol. 16, No. 5, 11.05.2015, p. 10665-10673.

Research output: Contribution to journalSpecial issue

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AU - Coleman, Michael

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AU - Karlgren-Andersson, Pernilla

AU - Renvert, Stefan

AU - Persson, G. Rutger

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Widén C, Coleman M, Critén S, Karlgren-Andersson P, Renvert S, Persson GR. Consumption of bilberries controls gingival inflammation. International Journal of Molecular Sciences. 2015 May 11;16(5):10665-10673. https://doi.org/10.3390/ijms160510665