Contact time periods in immunological synapse

Daniel R. Bush*, Amit K. Chattopadhyay

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

This paper resolves the long standing debate as to the proper time scale τ of the onset of the immunological synapse bond, the noncovalent chemical bond defining the immune pathways involving T cells and antigen presenting cells. Results from our model calculations show τ to be of the order of seconds instead of minutes. Close to the linearly stable regime, we show that in between the two critical spatial thresholds defined by the integrin:ligand pair (Δ2∼ 40-45 nm) and the T-cell receptor TCR:peptide-major-histocompatibility-complex pMHC bond (Δ1∼ 14-15 nm), τ grows monotonically with increasing coreceptor bond length separation δ (= Δ2-Δ1∼ 26-30 nm) while τ decays with Δ1 for fixed Δ2. The nonuniversal δ-dependent power-law structure of the probability density function further explains why only the TCR:pMHC bond is a likely candidate to form a stable synapse.

Original languageEnglish
Article number042706
Number of pages6
JournalPhysical Review E
Volume90
Issue number4
DOIs
Publication statusPublished - 8 Oct 2014

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synapses
Synapse
T-cells
Integrin
Contact
antigens
chemical bonds
probability density functions
Peptides
Receptor
Probability density function
peptides
Pathway
Resolve
Power Law
Time Scales
Linearly
Likely
Decay
ligands

Bibliographical note

©2014 American Physical Society

Cite this

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Contact time periods in immunological synapse. / Bush, Daniel R.; Chattopadhyay, Amit K.

In: Physical Review E, Vol. 90, No. 4, 042706, 08.10.2014.

Research output: Contribution to journalArticle

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