Control of shape and size of poly (lactic acid) microspheres based on surfactant and polymer concentration

Barkha Singh, Pushpendra Singh, Andrew J. Sutherland, Kaushik Pal

Research output: Contribution to journalArticle

Abstract

Biodegradable, poly (lactic acid) (PLA) microspheres have been synthesized via solvent evaporation method using ultrasonic homogenizer as emulsifier. The effect of added surfactant, PVA [poly (vinyl alcohol)], and PLA concentration on the shape and size of the resultant PLA microspheres has been studied. The prime objective of this work was to identify an optimal PVA/PLA concentration to prepare PLA microsphere with a size distribution of 1–2 micrometers as in many literature it has been reported as ideal range of size for non-endocytosis-mediated cellular drug delivery. In this pursuit it was found that an optimal concentration of 2.5% w/v of PVA into water and 2.5% w/v PLA into DCM [Dichloromethane] is suitable to create PLA microspheres with a size distribution of 1–2 micrometers. The PLA microspheres were characterized by FESEM to assess their shape and size. FT-IR analysis (Supplementary data) was used to assess the functional groups present in the PLA microspheres, whilst zeta-potential measurements (Supplementary data) provided insight into the likely dispersion properties of the microspheres in aqueous media.

LanguageEnglish
Pages48-51
Number of pages4
JournalMaterials Letters
Volume195
Early online date21 Feb 2017
DOIs
Publication statusPublished - 15 May 2017

Fingerprint

lactic acid
Lactic acid
Microspheres
Surface-Active Agents
Polymers
Surface active agents
surfactants
micrometers
polymers
delivery
drugs
alcohols
ultrasonics
evaporation
Methylene Chloride
Dichloromethane
water
Zeta potential
poly(lactic acid)
Drug delivery

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • poly (lactic acid)
  • PLA
  • microspheres
  • probe-based ultrasonication
  • FESEM
  • FT-IR spectroscopy

Cite this

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abstract = "Biodegradable, poly (lactic acid) (PLA) microspheres have been synthesized via solvent evaporation method using ultrasonic homogenizer as emulsifier. The effect of added surfactant, PVA [poly (vinyl alcohol)], and PLA concentration on the shape and size of the resultant PLA microspheres has been studied. The prime objective of this work was to identify an optimal PVA/PLA concentration to prepare PLA microsphere with a size distribution of 1–2 micrometers as in many literature it has been reported as ideal range of size for non-endocytosis-mediated cellular drug delivery. In this pursuit it was found that an optimal concentration of 2.5{\%} w/v of PVA into water and 2.5{\%} w/v PLA into DCM [Dichloromethane] is suitable to create PLA microspheres with a size distribution of 1–2 micrometers. The PLA microspheres were characterized by FESEM to assess their shape and size. FT-IR analysis (Supplementary data) was used to assess the functional groups present in the PLA microspheres, whilst zeta-potential measurements (Supplementary data) provided insight into the likely dispersion properties of the microspheres in aqueous media.",
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Control of shape and size of poly (lactic acid) microspheres based on surfactant and polymer concentration. / Singh, Barkha; Singh, Pushpendra; Sutherland, Andrew J.; Pal, Kaushik.

In: Materials Letters, Vol. 195, 15.05.2017, p. 48-51.

Research output: Contribution to journalArticle

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