Controlled Adverse Environment Chambers in Dry Eye Research

Margarita Calonge, Marc Labetoulle, Elisabeth M Messmer, Sunil Shah, Yonca A Akova, Kostas G Boboridis, Jesús Merayo-Lloves, Pasquale Aragona, José Benítez-Del-Castillo, Gerd Geerling, Maurizio Rolando, Christophe Baudouin

Research output: Contribution to journalReview article

Abstract

Dry eye disease (DED) is a common condition with signs and symptoms that vary depending on a wide range of environmental factors to which people are exposed in their daily lives. Factors such as variable temperature, airflow velocity, relative humidity, seasonality, and pollutants can alter the rate of tear film evaporation, improving or exacerbating symptoms of DED. Results from currently available clinical tests do not always correlate well with patient-reported symptoms, and the continually changing environment and variability in DED symptoms present challenges for the design and conduct of clinical trials. Controlled adverse environment chambers allow standardization of temperature, humidity, and airflow and may minimize potential confounding factors in clinical investigations. Their use can promote accurate study of the pathophysiology of DED, discovery of disease biomarkers, and assessment of the effect of various therapeutic approaches on patients' symptoms. Controlled adverse environment chambers have been used to simulate indoor surroundings such as airplane cabins and to test their effects on contact lens wearers. This review summarizes how these chambers may be useful for the development, approval, and differentiation of potential new treatments for DED.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalCurrent Eye Research
Volume43
Issue number4
Early online date16 Jan 2018
DOIs
Publication statusPublished - Apr 2018

Fingerprint

Controlled Environment
Eye Diseases
Research
Humidity
Temperature
Aircraft
Contact Lenses
Therapeutic Uses
Tears
Signs and Symptoms
Biomarkers
Clinical Trials

Keywords

  • Dry Eye Syndromes/epidemiology
  • Environment, Controlled
  • Environmental Exposure/adverse effects
  • Global Health
  • Humans
  • Humidity
  • Incidence
  • Seasons
  • Temperature

Cite this

Calonge, M., Labetoulle, M., Messmer, E. M., Shah, S., Akova, Y. A., Boboridis, K. G., ... Baudouin, C. (2018). Controlled Adverse Environment Chambers in Dry Eye Research. Current Eye Research, 43(4), 445-450. https://doi.org/10.1080/02713683.2017.1420197
Calonge, Margarita ; Labetoulle, Marc ; Messmer, Elisabeth M ; Shah, Sunil ; Akova, Yonca A ; Boboridis, Kostas G ; Merayo-Lloves, Jesús ; Aragona, Pasquale ; Benítez-Del-Castillo, José ; Geerling, Gerd ; Rolando, Maurizio ; Baudouin, Christophe. / Controlled Adverse Environment Chambers in Dry Eye Research. In: Current Eye Research. 2018 ; Vol. 43, No. 4. pp. 445-450.
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Calonge, M, Labetoulle, M, Messmer, EM, Shah, S, Akova, YA, Boboridis, KG, Merayo-Lloves, J, Aragona, P, Benítez-Del-Castillo, J, Geerling, G, Rolando, M & Baudouin, C 2018, 'Controlled Adverse Environment Chambers in Dry Eye Research', Current Eye Research, vol. 43, no. 4, pp. 445-450. https://doi.org/10.1080/02713683.2017.1420197

Controlled Adverse Environment Chambers in Dry Eye Research. / Calonge, Margarita; Labetoulle, Marc; Messmer, Elisabeth M; Shah, Sunil; Akova, Yonca A; Boboridis, Kostas G; Merayo-Lloves, Jesús; Aragona, Pasquale; Benítez-Del-Castillo, José; Geerling, Gerd; Rolando, Maurizio; Baudouin, Christophe.

In: Current Eye Research, Vol. 43, No. 4, 04.2018, p. 445-450.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Controlled Adverse Environment Chambers in Dry Eye Research

AU - Calonge, Margarita

AU - Labetoulle, Marc

AU - Messmer, Elisabeth M

AU - Shah, Sunil

AU - Akova, Yonca A

AU - Boboridis, Kostas G

AU - Merayo-Lloves, Jesús

AU - Aragona, Pasquale

AU - Benítez-Del-Castillo, José

AU - Geerling, Gerd

AU - Rolando, Maurizio

AU - Baudouin, Christophe

PY - 2018/4

Y1 - 2018/4

N2 - Dry eye disease (DED) is a common condition with signs and symptoms that vary depending on a wide range of environmental factors to which people are exposed in their daily lives. Factors such as variable temperature, airflow velocity, relative humidity, seasonality, and pollutants can alter the rate of tear film evaporation, improving or exacerbating symptoms of DED. Results from currently available clinical tests do not always correlate well with patient-reported symptoms, and the continually changing environment and variability in DED symptoms present challenges for the design and conduct of clinical trials. Controlled adverse environment chambers allow standardization of temperature, humidity, and airflow and may minimize potential confounding factors in clinical investigations. Their use can promote accurate study of the pathophysiology of DED, discovery of disease biomarkers, and assessment of the effect of various therapeutic approaches on patients' symptoms. Controlled adverse environment chambers have been used to simulate indoor surroundings such as airplane cabins and to test their effects on contact lens wearers. This review summarizes how these chambers may be useful for the development, approval, and differentiation of potential new treatments for DED.

AB - Dry eye disease (DED) is a common condition with signs and symptoms that vary depending on a wide range of environmental factors to which people are exposed in their daily lives. Factors such as variable temperature, airflow velocity, relative humidity, seasonality, and pollutants can alter the rate of tear film evaporation, improving or exacerbating symptoms of DED. Results from currently available clinical tests do not always correlate well with patient-reported symptoms, and the continually changing environment and variability in DED symptoms present challenges for the design and conduct of clinical trials. Controlled adverse environment chambers allow standardization of temperature, humidity, and airflow and may minimize potential confounding factors in clinical investigations. Their use can promote accurate study of the pathophysiology of DED, discovery of disease biomarkers, and assessment of the effect of various therapeutic approaches on patients' symptoms. Controlled adverse environment chambers have been used to simulate indoor surroundings such as airplane cabins and to test their effects on contact lens wearers. This review summarizes how these chambers may be useful for the development, approval, and differentiation of potential new treatments for DED.

KW - Dry Eye Syndromes/epidemiology

KW - Environment, Controlled

KW - Environmental Exposure/adverse effects

KW - Global Health

KW - Humans

KW - Humidity

KW - Incidence

KW - Seasons

KW - Temperature

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U2 - 10.1080/02713683.2017.1420197

DO - 10.1080/02713683.2017.1420197

M3 - Review article

C2 - 29336696

VL - 43

SP - 445

EP - 450

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 4

ER -

Calonge M, Labetoulle M, Messmer EM, Shah S, Akova YA, Boboridis KG et al. Controlled Adverse Environment Chambers in Dry Eye Research. Current Eye Research. 2018 Apr;43(4):445-450. https://doi.org/10.1080/02713683.2017.1420197