Copper complexes as a source of redox active MRI contrast agents

Lynsey Dunbar, Rebecca J. Sowden, Katherine D. Trotter, Michelle K. Taylor, David Smith, Alan R. Kennedy, John Reglinski*, Corinne M. Spickett

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

Original languageEnglish
Pages (from-to)903-912
Number of pages10
JournalBioMetals
Volume28
Issue number5
Early online date9 Aug 2015
DOIs
Publication statusPublished - 2015

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Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3

Funding: BBSRC (BBS/B/01553).

Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).

Keywords

  • copper macrocycles
  • oxidation–reduction
  • Redox sensitive contrast agent
  • imaging
  • inflammation

Cite this

Dunbar, L., Sowden, R. J., Trotter, K. D., Taylor, M. K., Smith, D., Kennedy, A. R., Reglinski, J., & Spickett, C. M. (2015). Copper complexes as a source of redox active MRI contrast agents. BioMetals, 28(5), 903-912. https://doi.org/10.1007/s10534-015-9875-3