Copper complexes as a source of redox active MRI contrast agents

Lynsey Dunbar, Rebecca J. Sowden, Katherine D. Trotter, Michelle K. Taylor, David Smith, Alan R. Kennedy, John Reglinski, Corinne M. Spickett

Research output: Contribution to journalArticle

Abstract

The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

LanguageEnglish
Pages903-912
Number of pages10
JournalBioMetals
Volume28
Issue number5
Early online date9 Aug 2015
DOIs
Publication statusPublished - 2015

Fingerprint

Magnetic resonance imaging
Contrast Media
Oxidation-Reduction
Copper
copper
Lanthanoid Series Elements
Switches

Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3

Funding: BBSRC (BBS/B/01553).

Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).

Keywords

  • copper macrocycles
  • oxidation–reduction
  • Redox sensitive contrast agent
  • imaging
  • inflammation

Cite this

Dunbar, L., Sowden, R. J., Trotter, K. D., Taylor, M. K., Smith, D., Kennedy, A. R., ... Spickett, C. M. (2015). Copper complexes as a source of redox active MRI contrast agents. BioMetals, 28(5), 903-912. https://doi.org/10.1007/s10534-015-9875-3
Dunbar, Lynsey ; Sowden, Rebecca J. ; Trotter, Katherine D. ; Taylor, Michelle K. ; Smith, David ; Kennedy, Alan R. ; Reglinski, John ; Spickett, Corinne M. / Copper complexes as a source of redox active MRI contrast agents. In: BioMetals. 2015 ; Vol. 28, No. 5. pp. 903-912.
@article{bdf8a07b6d4048daa0485d217590f5a3,
title = "Copper complexes as a source of redox active MRI contrast agents",
abstract = "The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.",
keywords = "copper macrocycles, oxidation–reduction, Redox sensitive contrast agent, imaging, inflammation",
author = "Lynsey Dunbar and Sowden, {Rebecca J.} and Trotter, {Katherine D.} and Taylor, {Michelle K.} and David Smith and Kennedy, {Alan R.} and John Reglinski and Spickett, {Corinne M.}",
note = "The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3 Funding: BBSRC (BBS/B/01553). Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).",
year = "2015",
doi = "10.1007/s10534-015-9875-3",
language = "English",
volume = "28",
pages = "903--912",
journal = "BioMetals",
issn = "0966-0844",
publisher = "Springer",
number = "5",

}

Dunbar, L, Sowden, RJ, Trotter, KD, Taylor, MK, Smith, D, Kennedy, AR, Reglinski, J & Spickett, CM 2015, 'Copper complexes as a source of redox active MRI contrast agents' BioMetals, vol. 28, no. 5, pp. 903-912. https://doi.org/10.1007/s10534-015-9875-3

Copper complexes as a source of redox active MRI contrast agents. / Dunbar, Lynsey; Sowden, Rebecca J.; Trotter, Katherine D.; Taylor, Michelle K.; Smith, David; Kennedy, Alan R.; Reglinski, John; Spickett, Corinne M.

In: BioMetals, Vol. 28, No. 5, 2015, p. 903-912.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Copper complexes as a source of redox active MRI contrast agents

AU - Dunbar, Lynsey

AU - Sowden, Rebecca J.

AU - Trotter, Katherine D.

AU - Taylor, Michelle K.

AU - Smith, David

AU - Kennedy, Alan R.

AU - Reglinski, John

AU - Spickett, Corinne M.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s10534-015-9875-3 Funding: BBSRC (BBS/B/01553). Electronic supplementary material (doi: 10.1007/s10534-015-9875-3).

PY - 2015

Y1 - 2015

N2 - The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

AB - The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

KW - copper macrocycles

KW - oxidation–reduction

KW - Redox sensitive contrast agent

KW - imaging

KW - inflammation

UR - http://www.scopus.com/inward/record.url?scp=84941995272&partnerID=8YFLogxK

U2 - 10.1007/s10534-015-9875-3

DO - 10.1007/s10534-015-9875-3

M3 - Article

VL - 28

SP - 903

EP - 912

JO - BioMetals

T2 - BioMetals

JF - BioMetals

SN - 0966-0844

IS - 5

ER -

Dunbar L, Sowden RJ, Trotter KD, Taylor MK, Smith D, Kennedy AR et al. Copper complexes as a source of redox active MRI contrast agents. BioMetals. 2015;28(5):903-912. https://doi.org/10.1007/s10534-015-9875-3