Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder

Mark Walterfang, Andrew M. Chanen, Sarah Barton, Amanda G. Wood, Sheena Jones, David C. Reutens, Jian Chen, Dennis Velakoulis, Patrick D. McGorry, Christos Pantelis

Research output: Contribution to journalArticle

Abstract

Previous studies have demonstrated alterations to fronto-limbic circuitry and callosal structure in borderline personality disorder (BPD). We predicted that a first-presentation BPD cohort who demonstrated orbitofrontal cortex (OFC) reductions would show regional reductions in the anterior corpus callosum.
Method: Twenty teenage first-presentation BPD patients and twenty matched healthy controls underwent Magnetic resonance imaging (MRI) was performed in 20 teenaged first-presentation BPD patients and 20 matched healthy controls. Corpus callosum size and shape and ventricular volume were estimated using established methods and compared between the two groups. The relationship between illness variables and callosal morphology was also examined. OFC volume was correlated with callosal and ventricular variables.
Results: BPD participants and controls did not differ on measures of callosal size or shape, or ventricular size. BPD participants showed an alteration to the pattern of age-related expansions seen in the callosum. BPD participants with a history of trauma did not demonstrate significant neuroanatomical differences from those without. OFC volumes did not correlate with the thickness of the anterior corpus callosum.
Conclusion: Gross neuroanatomical changes are not present at the level of the callosum in teenagers with first-presentation BPD. Changes seen in other studies might reflect factors associated with the duration of BPD, such as recurrent comorbidity with axis I disorders, or treatment.
Original languageEnglish
Pages (from-to)30–37
Number of pages8
JournalPsychiatry Research
Volume183
Issue number1
Early online date3 Jun 2010
DOIs
Publication statusPublished - 30 Jul 2010

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Borderline Personality Disorder
Corpus Callosum
Prefrontal Cortex
Comorbidity
Magnetic Resonance Imaging

Keywords

  • Myelin
  • white matter
  • prefrontal cortex

Cite this

Walterfang, Mark ; Chanen, Andrew M. ; Barton, Sarah ; Wood, Amanda G. ; Jones, Sheena ; Reutens, David C. ; Chen, Jian ; Velakoulis, Dennis ; McGorry, Patrick D. ; Pantelis, Christos. / Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder. In: Psychiatry Research. 2010 ; Vol. 183, No. 1. pp. 30–37.
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author = "Mark Walterfang and Chanen, {Andrew M.} and Sarah Barton and Wood, {Amanda G.} and Sheena Jones and Reutens, {David C.} and Jian Chen and Dennis Velakoulis and McGorry, {Patrick D.} and Christos Pantelis",
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Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder. / Walterfang, Mark; Chanen, Andrew M.; Barton, Sarah; Wood, Amanda G.; Jones, Sheena; Reutens, David C.; Chen, Jian; Velakoulis, Dennis; McGorry, Patrick D.; Pantelis, Christos.

In: Psychiatry Research, Vol. 183, No. 1, 30.07.2010, p. 30–37.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Corpus callosum morphology and relationship to orbitofrontal and lateral ventricular volume in teenagers with first-presentation borderline personality disorder

AU - Walterfang, Mark

AU - Chanen, Andrew M.

AU - Barton, Sarah

AU - Wood, Amanda G.

AU - Jones, Sheena

AU - Reutens, David C.

AU - Chen, Jian

AU - Velakoulis, Dennis

AU - McGorry, Patrick D.

AU - Pantelis, Christos

PY - 2010/7/30

Y1 - 2010/7/30

N2 - Previous studies have demonstrated alterations to fronto-limbic circuitry and callosal structure in borderline personality disorder (BPD). We predicted that a first-presentation BPD cohort who demonstrated orbitofrontal cortex (OFC) reductions would show regional reductions in the anterior corpus callosum. Method: Twenty teenage first-presentation BPD patients and twenty matched healthy controls underwent Magnetic resonance imaging (MRI) was performed in 20 teenaged first-presentation BPD patients and 20 matched healthy controls. Corpus callosum size and shape and ventricular volume were estimated using established methods and compared between the two groups. The relationship between illness variables and callosal morphology was also examined. OFC volume was correlated with callosal and ventricular variables. Results: BPD participants and controls did not differ on measures of callosal size or shape, or ventricular size. BPD participants showed an alteration to the pattern of age-related expansions seen in the callosum. BPD participants with a history of trauma did not demonstrate significant neuroanatomical differences from those without. OFC volumes did not correlate with the thickness of the anterior corpus callosum. Conclusion: Gross neuroanatomical changes are not present at the level of the callosum in teenagers with first-presentation BPD. Changes seen in other studies might reflect factors associated with the duration of BPD, such as recurrent comorbidity with axis I disorders, or treatment.

AB - Previous studies have demonstrated alterations to fronto-limbic circuitry and callosal structure in borderline personality disorder (BPD). We predicted that a first-presentation BPD cohort who demonstrated orbitofrontal cortex (OFC) reductions would show regional reductions in the anterior corpus callosum. Method: Twenty teenage first-presentation BPD patients and twenty matched healthy controls underwent Magnetic resonance imaging (MRI) was performed in 20 teenaged first-presentation BPD patients and 20 matched healthy controls. Corpus callosum size and shape and ventricular volume were estimated using established methods and compared between the two groups. The relationship between illness variables and callosal morphology was also examined. OFC volume was correlated with callosal and ventricular variables. Results: BPD participants and controls did not differ on measures of callosal size or shape, or ventricular size. BPD participants showed an alteration to the pattern of age-related expansions seen in the callosum. BPD participants with a history of trauma did not demonstrate significant neuroanatomical differences from those without. OFC volumes did not correlate with the thickness of the anterior corpus callosum. Conclusion: Gross neuroanatomical changes are not present at the level of the callosum in teenagers with first-presentation BPD. Changes seen in other studies might reflect factors associated with the duration of BPD, such as recurrent comorbidity with axis I disorders, or treatment.

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