Correlation of degradation in metronidazole infusion with F0 applied during steam sterilization at 122°C

A.R. Barnes, D.J. Makohon

Research output: Contribution to journalArticle

Abstract

Metronidazole infusion was sterilized in an autoclave at 122°C for different values of F0 up to 65.3 min. Both metronidazole degradation and the Production of nitrite ion correlated with F0. A typical sterilization cycle of approx. 121°C for 15 min. is likely to lead to 1.5-2% loss of metronidazole and the production of 1.5 ppm nitrite. The yield of nitrite was only 3-9% of the metronidazole destroyed.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume92
Issue number1-3
DOIs
Publication statusPublished - 3 May 1993

Keywords

  • autoclaving
  • degradation
  • F(0)
  • metronidazole
  • nitrite
  • sterilization

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