Corticobasal degeneration and dementia

R.A. Armstrong

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Corticobasal degeneration is a rare, progressive neurodegenerative disorder which significantly impairs movement. The most common initial symptom is asymmetric limb clumsiness with or without accompanying rigidity or tremor. Subsequently, the disease progresses to affect gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs. Clinical diagnosis of the disorder is difficult as the symptoms resemble those of related neurodegenerative disorders. Histopathologically, there is widespread neuronal and glial pathology including tau-immunoreactive neuronal cytoplasmic inclusions, neuropil threads, oligodendroglial inclusions, astrocytic plaques, together with abnormally enlarged ‘ballooned’ neurons. Corticobasal degeneration has affinities both with the parkinsonian syndromes including Parkinson’s disease, progressive supranuclear palsy, and multiple system atrophy and with the fronto-temporal dementias. Treatment of corticobasal degeneration involves managing and reducing the effect of symptoms.
LanguageEnglish
Title of host publicationDiet and nutrition in dementia and cognitive decline
EditorsColin R. Martin, Victor R. Preedy
Place of PublicationLondon (UK)
PublisherElsevier
Pages35-43
Number of pages9
ISBN (Print)978-0-12-407824-6
DOIs
Publication statusPublished - 2015

Fingerprint

Neurodegenerative Diseases
Dementia
Neuropil Threads
Progressive Supranuclear Palsy
Multiple System Atrophy
Apraxias
Inclusion Bodies
Parkinsonian Disorders
Tremor
Gait
Neuroglia
Parkinson Disease
Leg
Arm
Extremities
Pathology
Neurons

Keywords

  • tauopathy
  • Parkinsonian syndrome
  • neuronal cytoplasmic inclusions
  • astrocytic plaques
  • corticobasal degeneration

Cite this

Armstrong, R. A. (2015). Corticobasal degeneration and dementia. In C. R. Martin, & V. R. Preedy (Eds.), Diet and nutrition in dementia and cognitive decline (pp. 35-43). London (UK): Elsevier. https://doi.org/10.1016/B978-0-12-407824-6.00004-5
Armstrong, R.A. / Corticobasal degeneration and dementia. Diet and nutrition in dementia and cognitive decline. editor / Colin R. Martin ; Victor R. Preedy. London (UK) : Elsevier, 2015. pp. 35-43
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Armstrong, RA 2015, Corticobasal degeneration and dementia. in CR Martin & VR Preedy (eds), Diet and nutrition in dementia and cognitive decline. Elsevier, London (UK), pp. 35-43. https://doi.org/10.1016/B978-0-12-407824-6.00004-5

Corticobasal degeneration and dementia. / Armstrong, R.A.

Diet and nutrition in dementia and cognitive decline. ed. / Colin R. Martin; Victor R. Preedy. London (UK) : Elsevier, 2015. p. 35-43.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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AB - Corticobasal degeneration is a rare, progressive neurodegenerative disorder which significantly impairs movement. The most common initial symptom is asymmetric limb clumsiness with or without accompanying rigidity or tremor. Subsequently, the disease progresses to affect gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs. Clinical diagnosis of the disorder is difficult as the symptoms resemble those of related neurodegenerative disorders. Histopathologically, there is widespread neuronal and glial pathology including tau-immunoreactive neuronal cytoplasmic inclusions, neuropil threads, oligodendroglial inclusions, astrocytic plaques, together with abnormally enlarged ‘ballooned’ neurons. Corticobasal degeneration has affinities both with the parkinsonian syndromes including Parkinson’s disease, progressive supranuclear palsy, and multiple system atrophy and with the fronto-temporal dementias. Treatment of corticobasal degeneration involves managing and reducing the effect of symptoms.

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Armstrong RA. Corticobasal degeneration and dementia. In Martin CR, Preedy VR, editors, Diet and nutrition in dementia and cognitive decline. London (UK): Elsevier. 2015. p. 35-43 https://doi.org/10.1016/B978-0-12-407824-6.00004-5