Corticobasal degeneration and dementia

R.A. Armstrong

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Corticobasal degeneration is a rare, progressive neurodegenerative disorder which significantly impairs movement. The most common initial symptom is asymmetric limb clumsiness with or without accompanying rigidity or tremor. Subsequently, the disease progresses to affect gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs. Clinical diagnosis of the disorder is difficult as the symptoms resemble those of related neurodegenerative disorders. Histopathologically, there is widespread neuronal and glial pathology including tau-immunoreactive neuronal cytoplasmic inclusions, neuropil threads, oligodendroglial inclusions, astrocytic plaques, together with abnormally enlarged ‘ballooned’ neurons. Corticobasal degeneration has affinities both with the parkinsonian syndromes including Parkinson’s disease, progressive supranuclear palsy, and multiple system atrophy and with the fronto-temporal dementias. Treatment of corticobasal degeneration involves managing and reducing the effect of symptoms.
Original languageEnglish
Title of host publicationDiet and nutrition in dementia and cognitive decline
EditorsColin R. Martin, Victor R. Preedy
Place of PublicationLondon (UK)
PublisherElsevier
Pages35-43
Number of pages9
ISBN (Print)978-0-12-407824-6
DOIs
Publication statusPublished - 2015

Keywords

  • tauopathy
  • Parkinsonian syndrome
  • neuronal cytoplasmic inclusions
  • astrocytic plaques
  • corticobasal degeneration

Fingerprint Dive into the research topics of 'Corticobasal degeneration and dementia'. Together they form a unique fingerprint.

  • Research Output

    • 1 Chapter (peer-reviewed)

    Dementia with Lewy bodies

    Armstrong, R. A., 10 Sep 2014, Diet and nutrition in dementia and cognitive decline. Martin, C. R. & Preedy, V. R. (eds.). London (UK): Academic Press, p. 91-99 9 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  • Cite this

    Armstrong, R. A. (2015). Corticobasal degeneration and dementia. In C. R. Martin, & V. R. Preedy (Eds.), Diet and nutrition in dementia and cognitive decline (pp. 35-43). Elsevier. https://doi.org/10.1016/B978-0-12-407824-6.00004-5