Corticobasal degeneration and dementia

R.A. Armstrong

Research output: Chapter in Book/Published conference outputChapter (peer-reviewed)peer-review


Corticobasal degeneration is a rare, progressive neurodegenerative disorder which significantly impairs movement. The most common initial symptom is asymmetric limb clumsiness with or without accompanying rigidity or tremor. Subsequently, the disease progresses to affect gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs. Clinical diagnosis of the disorder is difficult as the symptoms resemble those of related neurodegenerative disorders. Histopathologically, there is widespread neuronal and glial pathology including tau-immunoreactive neuronal cytoplasmic inclusions, neuropil threads, oligodendroglial inclusions, astrocytic plaques, together with abnormally enlarged ‘ballooned’ neurons. Corticobasal degeneration has affinities both with the parkinsonian syndromes including Parkinson’s disease, progressive supranuclear palsy, and multiple system atrophy and with the fronto-temporal dementias. Treatment of corticobasal degeneration involves managing and reducing the effect of symptoms.
Original languageEnglish
Title of host publicationDiet and nutrition in dementia and cognitive decline
EditorsColin R. Martin, Victor R. Preedy
Place of PublicationLondon (UK)
Number of pages9
ISBN (Print)978-0-12-407824-6
Publication statusPublished - 2015


  • tauopathy
  • Parkinsonian syndrome
  • neuronal cytoplasmic inclusions
  • astrocytic plaques
  • corticobasal degeneration


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  • Dementia with Lewy bodies

    Armstrong, R. A., 10 Sept 2014, Diet and nutrition in dementia and cognitive decline. Martin, C. R. & Preedy, V. R. (eds.). London (UK): Academic Press, p. 91-99 9 p.

    Research output: Chapter in Book/Published conference outputChapter (peer-reviewed)peer-review

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