Coupling of Heck and hydrogenation reactions in a continuous compact reactor

Xiaolei Fan, Maria Gonzalez Manchon, Karen Wilson, Steve Tennison, Alexander Kozynchenko, Alexei A. Lapkin, Pawel K. Plucinski

Research output: Contribution to journalArticle

Abstract

A continuous multi-step synthesis of 1,2-diphenylethane was performed sequentially in a structured compact reactor. This process involved a Heck C-C coupling reaction followed by the addition of hydrogen to perform reduction of the intermediate obtained in the first step. Both of the reactions were catalysed by microspherical carbon-supported Pd catalysts. Due to the integration of the micro-heat exchanger, the static mixer and the mesoscale packed-bed reaction channel, the compact reactor was proven to be an intensified tool for promoting the reactions. In comparison with the batch reactor, this flow process in the compact reactor was more efficient as: (i) the reaction time was significantly reduced (ca. 7 min versus several hours), (ii) no additional ligands were used and (iii) the reaction was run at lower operational pressure and temperature. Pd leached in the Heck reaction step was shown to be effectively recovered in the following hydrogenation reaction section and the catalytic activity of the system can be mostly retained by reverse flow operation.
Original languageEnglish
Pages (from-to)114-120
Number of pages7
JournalJournal of Catalysis
Volume267
Issue number2
Early online date10 Sep 2009
DOIs
Publication statusPublished - 25 Oct 2009

Fingerprint

Batch reactors
Packed beds
Catalyst supports
Hydrogenation
hydrogenation
Heat exchangers
Hydrogen
Catalyst activity
Carbon
Ligands
reactors
Temperature
heat exchangers
1,2-dihydrostilbene
reaction time
catalytic activity
beds
catalysts
ligands
carbon

Keywords

  • flow chemistry
  • compact reactors
  • multifunctional reactors
  • tandem reactions

Cite this

Fan, X., Gonzalez Manchon, M., Wilson, K., Tennison, S., Kozynchenko, A., Lapkin, A. A., & Plucinski, P. K. (2009). Coupling of Heck and hydrogenation reactions in a continuous compact reactor. Journal of Catalysis, 267(2), 114-120. https://doi.org/10.1016/j.jcat.2009.07.019
Fan, Xiaolei ; Gonzalez Manchon, Maria ; Wilson, Karen ; Tennison, Steve ; Kozynchenko, Alexander ; Lapkin, Alexei A. ; Plucinski, Pawel K. / Coupling of Heck and hydrogenation reactions in a continuous compact reactor. In: Journal of Catalysis. 2009 ; Vol. 267, No. 2. pp. 114-120.
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Fan, X, Gonzalez Manchon, M, Wilson, K, Tennison, S, Kozynchenko, A, Lapkin, AA & Plucinski, PK 2009, 'Coupling of Heck and hydrogenation reactions in a continuous compact reactor', Journal of Catalysis, vol. 267, no. 2, pp. 114-120. https://doi.org/10.1016/j.jcat.2009.07.019

Coupling of Heck and hydrogenation reactions in a continuous compact reactor. / Fan, Xiaolei; Gonzalez Manchon, Maria; Wilson, Karen; Tennison, Steve; Kozynchenko, Alexander; Lapkin, Alexei A.; Plucinski, Pawel K.

In: Journal of Catalysis, Vol. 267, No. 2, 25.10.2009, p. 114-120.

Research output: Contribution to journalArticle

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Fan X, Gonzalez Manchon M, Wilson K, Tennison S, Kozynchenko A, Lapkin AA et al. Coupling of Heck and hydrogenation reactions in a continuous compact reactor. Journal of Catalysis. 2009 Oct 25;267(2):114-120. https://doi.org/10.1016/j.jcat.2009.07.019