CPFTransGAN: A Cross Perception Fusion Transformer-based Generative Adversarial Network for Head and Neck Cancer Dose Prediction in Radiotherapy

Radiation therapy is one of the primary treatment modalities for head and neck (H&N) cancer in clinical practice, aiming to deliver sufficient dose to Planning Target Volume (PTV) while protecting surrounding Organs at Risk (OAR) from or minimizing exposure to radiation. Quantitative dose prediction of various tissues and organs is a prerequisite for implementing intelligent precision radiotherapy. In order to improve dose prediction accuracy, we propose a generative adversarial network CPFTrans- GAN based on Cross Perception Fusion Transformer (CPF Transformer). Specifically, we design a CPF Transformer module through deeply integrating CNN and Transformer. Using the CPF Transformer as basic unit, we constructed a generator with four-stage encoding-decoding structure called CPFTransGenerator. An adaptive weight loss is used to train the discriminator to alleviate the issues of imbalance training in adversarial learning. To further improve the prediction accuracy, a multiscale cross-window encoding network is designed, which can constrain the differences between predicted dose and the reference one at different granularity levels by calculating feature losses between them at different scales. The proposed method is evaluated on two public head and neck cancer datasets and a local clinical dataset. Extensive experiments demonstrate the superior performance of our method compared with the state-of-the-art ones.