Current formulation approaches in design and development of solid oral dosage forms through three-dimensional printing

Research output: Contribution to journalReview article

Abstract

Three-dimensional (3D) printing technologies are continuously applied to novel fields, laying the foundations for a new industrial revolution. With regard to pharmaceutical sciences, 3D printed drug products are emerging as attractive and innovative tools in personalised medicine. For example, solid oral dosage forms (e.g. tablets) can be printed in a wide range of dosages, release profiles, geometries and sizes by simply modifying a digital model, thus providing patients with tailored therapies. Various 3D printing technologies have been applied to pharmaceutical manufacture in recent years, and different materials have been investigated to fabricate solid oral dosage forms in a broad range of properties. Therefore, the aim of this review is to describe the state of the art of 3D printing oral pharmaceuticals, with the view to provide formulation scientists with essential information to approach the development of 3D printed drug products, from digital design to final product quality control. Short- to long-term potential areas of application of 3D printed drug products and their relative regulatory pathway challenges are also presented.
Original languageEnglish
Pages (from-to)111-123
Number of pages13
JournalProgress in Additive Manufacturing
Volume5
Issue number2
Early online date21 Mar 2020
DOIs
Publication statusPublished - 1 Jun 2020

Bibliographical note

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Keywords

  • Drug delivery
  • Personalised medicine
  • Solid oral dosage forms
  • Three-dimensional printing

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